Document Detail


Prohemostatic interventions in obstetric hemorrhage.
MedLine Citation:
PMID:  22510859     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Obstetric hemorrhage is a major cause of maternal morbidity and mortality. Pregnancy is associated with substantial hemostatic changes, resulting in a relatively hypercoagulable state. Acquired coagulopathy can, however, develop rapidly in severe obstetric hemorrhage. Therefore, prohemostatic treatments based on high fresh frozen plasma and red blood cell (FFP:RBC) ratio transfusion and procoagulant agents (fibrinogen concentrates, recombinant activated factor VII, and tranexamic acid) are crucial aspects of management. Often, evidence from trauma patients is applied to obstetric hemorrhage management, although distinct differences exist between the two situations. Therefore, until efficacy and safety are demonstrated in obstetric hemorrhage, clinicians should be cautious about wholesale adoption of high FFP:RBC ratio products. Applications of transfusion protocols, dedicated to massive obstetric hemorrhage and multidisciplinarily developed, currently remain the best available option. Similarly, while procoagulant agents appear promising in treatment of obstetric hemorrhage, caution is nonetheless warranted as long as clear evidence in the context of obstetric hemorrhage is lacking.
Authors:
Marie-Pierre Bonnet; Olga Basso
Related Documents :
11129689 - Long-term effects on offspring of exposure of oocytes and embryos to chemical and physi...
21306979 - Exposure to polycyclic aromatic hydrocarbons and newborn biometric indicators.
19863469 - Embryonic development and pregnancy test sensitivity: the importance of earlier pregnan...
7955569 - Developmental arrest of fertilized eggs from the b6.ydom sex-reversed female mouse.
2518159 - Microgravity effects on the oogenesis and development of embryos of drosophila melanoga...
8954739 - The establishment of embryonic axial properties in the nemertean, cerebratulus lacteus.
1388439 - Treatment and outcomes of psychotic patients during pregnancy and childbirth.
24796309 - The effect of maternal body mass index on fetal growth: use of individualized growth as...
3307429 - The presence or absence of fetal breathing movements as a predictor of outcome in prete...
Publication Detail:
Type:  Journal Article     Date:  2012-02-18
Journal Detail:
Title:  Seminars in thrombosis and hemostasis     Volume:  38     ISSN:  1098-9064     ISO Abbreviation:  Semin. Thromb. Hemost.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0431155     Medline TA:  Semin Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-64     Citation Subset:  IM    
Copyright Information:
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Affiliation:
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prohemostatic interventions in liver surgery.
Next Document:  Vatreptacog alfa from conception to clinical proof of concept.