| Progressive tree neighborhood applied to the maximum parsimony problem. | |
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MedLine Citation:
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PMID: 18245882 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Maximum Parsimony (MP) problem aims at reconstructing a phylogenetic tree from DNA sequences while minimizing the number of genetic transformations. To solve this NP-complete problem, heuristic methods have been developed, often based on local search. In this article, we focus on the influence of the neighborhood relations. After analyzing the advantages and drawbacks of the well-known Nearest Neighbor Interchange (NNI), Subtree Pruning Regrafting (SPR) and Tree-Bisection-Reconnection (TBR) neighborhoods, we introduce the concept of Progressive Neighborhood (PN) which consists in constraining progressively the size of the neighborhood as the search advances. We empirically show that applied to the Maximum Parsimony problem, this progressive neighborhood turns out to be more efficient and robust than the classic neighborhoods using a descent algorithm. Indeed, it allows to find better solutions with a smaller number of iterations or trees evaluated. |
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Authors:
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Adrien Goëffon; Jean-Michel Richer; Jin-Kao Hao |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: IEEE/ACM transactions on computational biology and bioinformatics / IEEE, ACM Volume: 5 ISSN: 1545-5963 ISO Abbreviation: IEEE/ACM Trans Comput Biol Bioinform Publication Date: 2008 Jan-Mar |
Date Detail:
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Created Date: 2008-02-04 Completed Date: 2008-05-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101196755 Medline TA: IEEE/ACM Trans Comput Biol Bioinform Country: United States |
Other Details:
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Languages: eng Pagination: 136-45 Citation Subset: IM |
Affiliation:
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University of Angers, Lavoisier, France. adrien.goeffon@univ-angers.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Base Sequence Evolution, Molecular Models, Genetic* Models, Statistical Phylogeny* Probability |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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