Document Detail

Progressive supranuclear palsy.
MedLine Citation:
PMID:  3315157     Owner:  NLM     Status:  MEDLINE    
Progressive supranuclear palsy (PSP) was first recognized as a distinct morbid entity by Richardson, Steele and Olszewski a quarter century ago. Subsequent experience has confirmed and extended their original observations. PSP has become familiar as a chronic progressive disorder with extrapyramidal rigidity, bradykinesia, gait impairment, bulbar palsy, dementia and a characteristic supranuclear ophthalmoplegia. It is an important cause of parkinsonism. Its etiology remains obscure. Familial concentrations have not been observed. Some cases exhibit no oculomotor dysfunction. Dementia is usually mild. Recent neuropsychological studies have defined features consistent with frontal lobe cortical dysfunction. Seizures and paroxysmal EEG activity may occur. CT and MRI scans show midbrain atrophy early and later atrophy of the pontine and midbrain tegmentum and the frontal and temporal lobes. PET scans have shown frontal hypometabolism and loss of striatal D-2 dopamine receptors. Postmortem studies have documented involvement of both dopaminergic and cholinergic systems. Treatment remains palliative and unsatisfactory.
R C Duvoisin; L I Golbe; F E Lepore
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques     Volume:  14     ISSN:  0317-1671     ISO Abbreviation:  Can J Neurol Sci     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1988-01-13     Completed Date:  1988-01-13     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0415227     Medline TA:  Can J Neurol Sci     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  547-54     Citation Subset:  IM    
Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903.
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MeSH Terms
Brain / pathology
Dementia / etiology
Epilepsy / etiology
Magnetic Resonance Imaging
Middle Aged
Ophthalmoplegia / etiology
Parkinson Disease / complications
Supranuclear Palsy, Progressive / complications,  diagnosis,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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