Document Detail


Progressive ratio and behavioral economic evaluation of the reinforcing efficacy of orally delivered phencyclidine and ethanol in monkeys: effects of feeding conditions.
MedLine Citation:
PMID:  8972546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of feeding conditions on the reinforcing efficacy of orally-delivered drugs was evaluated using a progressive-ratio (PR) paradigm and a behavioral economic analysis of demand. Seven monkeys self-administered phencyclidine (PCP) (0.06, 0.12, 0.25, 0.5, and 1.0 mg/ml) or ethanol (2, 4, 8, 16, and 32% wt/vol) and concurrent water from two drinking spouts under concurrent PR schedules. The ratios increased from 8 to 4096, and 40 liquid deliveries were available after completion of each ratio schedule. The entire range of drug concentrations was presented in nonsystematic order under two feeding conditions, food restriction and food satiation. Drug maintained responses, deliveries and break points were significantly greater than those maintained by water. Food restriction significantly increased the rate of PCP-maintained responses, deliveries and PR break points over the food satiation baseline. There was also a significant interaction between feeding condition and drug concentration. Although ethanol-maintained responses, liquid deliveries and break points consistently increased in five of seven monkeys during food restriction, only drug concentration produced significant differences in these measures. Using break point as a measure of reinforcing efficacy, food restriction increased the reinforcing efficacy of PCP and had a more pronounced effect at higher drug unit prices.
Authors:
J S Rodefer; M E Carroll
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychopharmacology     Volume:  128     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-03-24     Completed Date:  1997-03-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  265-73     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455-0392, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Analysis of Variance
Animals
Behavior, Animal / drug effects*
Dose-Response Relationship, Drug
Ethanol / pharmacology*
Feeding Behavior / drug effects*
Food Deprivation / physiology
Hallucinogens / pharmacology*
Macaca mulatta
Male
Phencyclidine / pharmacology*
Reinforcement Schedule*
Satiation / physiology
Self Medication / psychology
Grant Support
ID/Acronym/Agency:
R01 DA02486/DA/NIDA NIH HHS; T32 DA 07097/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Hallucinogens; 64-17-5/Ethanol; 77-10-1/Phencyclidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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