Document Detail

Progressive pulmonary vascular disease after pulmonary artery banding and total correction in a case of ventricular septal defect and pulmonary hypertension.
MedLine Citation:
PMID:  10402773     Owner:  NLM     Status:  MEDLINE    
A 7-month-old infant with ventricular septal defect and pulmonary hypertension underwent pulmonary artery banding, which resulted in a decrease in the pulmonary arterial peak pressure from 102 to 54 mmHg. Lung biopsy findings showed at most an early grade 3 Heath-Edwards classification, and an index of pulmonary vascular disease of 1.4, both of which indicated operability for total correction. Small pulmonary arteries less than 100 microns in diameter, however, showed marked hydropic changes in the medial smooth muscle cells. Total correction was performed at the age of 2 years, but the pulmonary arterial pressure failed to decrease. A lung biopsy taken just after the closure of the ventricular septal defect contraindicated operability due to progressive pulmonary vascular disease at a grade 6 Heath-Edwards classification and an index of pulmonary vascular disease of 2.4. The patient died at 8 months after the operation, and an autopsy revealed still more advanced pulmonary vascular disease at a grade 6 Heath-Edwards classification and an index of pulmonary vascular disease of 2.8. The pathogenesis of arterial changes is discussed.
S Yamaki; S Yonesaka; S Suzuki; K Nagumo; K Ouchi; T Takahashi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi     Volume:  47     ISSN:  1344-4964     ISO Abbreviation:  Jpn. J. Thorac. Cardiovasc. Surg.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-09-22     Completed Date:  1999-09-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100884261     Medline TA:  Jpn J Thorac Cardiovasc Surg     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  229-33     Citation Subset:  IM    
Department of Cardiology, Katta General Hospital, Miyagi, Japan.
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MeSH Terms
Disease Progression
Heart Septal Defects, Ventricular / complications,  surgery*
Hypertension, Pulmonary / etiology*,  pathology,  surgery
Postoperative Complications*
Pulmonary Artery / pathology,  surgery*
Vascular Surgical Procedures

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