| Progressive primary pulmonary tuberculosis presenting as the sudden unexpected death in infancy: a case report. | |
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MedLine Citation:
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PMID: 20705406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The classification of an unexpected infant death as the sudden infant death syndrome (SIDS) depends upon a complete autopsy and death scene investigation to exclude known causes of death. Here we report the death of a 4-month-old infant in a tuberculosis endemic area that presented as a sudden unexpected death in infancy (SUDI) with no apparent explanation based on the death scene characteristics. The autopsy, however, revealed progressive primary pulmonary tuberculosis with intrathoracicadenopathy, compression of the tracheobronchial tree and miliary lesions in the liver. This case underscores the clinical difficulties in the diagnosis of infantile tuberculosis, as well as the possibility of sudden death as part of its protean manifestations. The pathology and clinical progression of tuberculosis in infants differ from older children and adults due to the immature immune response in infants. This case dramatically highlights the need for complete autopsies in all sudden and unexpected infant deaths, as well as the public health issues in a sentinel infant tuberculosis diagnosis. |
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Authors:
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Johan Dempers; Mary Ann Sens; Shabbir Ahmed Wadee; Hannah C Kinney; Hein J Odendaal; Colleen A Wright; |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural Date: 2010-08-11 |
Journal Detail:
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Title: Forensic science international Volume: 206 ISSN: 1872-6283 ISO Abbreviation: Forensic Sci. Int. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-14 Completed Date: 2011-07-26 Revised Date: 2012-09-24 |
Medline Journal Info:
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Nlm Unique ID: 7902034 Medline TA: Forensic Sci Int Country: Ireland |
Other Details:
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Languages: eng Pagination: e27-30 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Division of Forensic Medicine and Pathology, Department of Pathology and Western Cape Forensic Pathology Services, Faculty of Health Science, Stellenbosch University, Tygerberg, South Africa. jd2@sun.ac.za |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Endemic Diseases Humans Infant Liver / pathology Lung / pathology Male South Africa Sudden Infant Death / etiology* Tuberculosis, Pulmonary / diagnosis*, epidemiology, transmission |
| Grant Support | |
ID/Acronym/Agency:
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U01 AA016501/AA/NIAAA NIH HHS; U01 AA016501-05/AA/NIAAA NIH HHS; U01 HD045935/HD/NICHD NIH HHS; U01 HD045935-08/HD/NICHD NIH HHS; U01 HD045991/HD/NICHD NIH HHS; U01 HD045991-08/HD/NICHD NIH HHS; U01 HD055154/HD/NICHD NIH HHS; U01 HD055154-08/HD/NICHD NIH HHS; U01 HD055155/HD/NICHD NIH HHS; U01 HD055155-05/HD/NICHD NIH HHS |
| Investigator | |
Investigator/Affiliation:
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Bradley Randall / ; Amy Elliott / ; Rebecca Folkerth / ; Larry Burd / ; Kimberly A Dukes / ; Amy Elliott / ; William P Fifer / ; Rebecca Folkerth / ; Gary Hankins / ; Dale Hereld / ; Michael M Myers / ; Caroline Signore / ; Lisa M Sullivan / ; Marian Willinger / |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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