| Progressive peritumoral edema defining the optic fibers and resulting in reversible visual loss. | |
| | |
MedLine Citation:
|
PMID: 18671645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hemangioblastomas are frequently associated with peritumoral edema caused by extravasation of plasma ultrafiltrate through permeable neoplastic vessels. The authors report the clinical and imaging findings in a 62-year-old man with von Hippel-Lindau disease who presented with rapid (within 24 hours) loss of color vision and nearcomplete loss of left eye vision (acuity too poor to test). Serial MR imaging demonstrated a stable vascular tumor in the medioinferior aspect of the left optic nerve, associated with progressive edema extending from the nerve through to the bilateral optic radiations. Complete resection of the lesion was performed via an extended transsphenoidal approach, and histological examination confirmed the lesion was a hemangioblastoma. Postoperatively, the patient recovered color vision and had improvement in visual acuity (20/320). Serial imaging in this unique case captured the progressive extravasation of peritumoral edema that tracked and defined the parallel white matter tracts of first- and second-order neurons of the optic system, causing vision loss. Tumor resection led to resolution of the edema and improvement in visual function. |
| | |
Authors:
|
Martin Baggenstos; Emily Chew; John A Butman; Edward H Oldfield; Russell R Lonser |
Related Documents
:
|
1736875 - Choristoma of the optic nerve and chiasm. 2152985 - Perineural tumor extension through the foramen ovale: evaluation with mr imaging. 18326695 - A primate model of nonarteritic anterior ischemic optic neuropathy. 2505515 - The radiologic assessment of trigeminal neuropathy. 9922085 - Reversible focal mri abnormalities due to status epilepticus. an eeg, single photon emi... 8106645 - Do thalamic lesions really cause vertical gaze palsies? |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, N.I.H., Intramural |
Journal Detail:
|
Title: Journal of neurosurgery Volume: 109 ISSN: 0022-3085 ISO Abbreviation: J. Neurosurg. Publication Date: 2008 Aug |
Date Detail:
|
Created Date: 2008-08-01 Completed Date: 2008-09-12 Revised Date: 2010-09-21 |
Medline Journal Info:
|
Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: United States |
Other Details:
|
Languages: eng Pagination: 313-7 Citation Subset: AIM; IM |
Affiliation:
|
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1414, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Brain Edema
/
etiology,
pathology* Color Perception Hemangioblastoma / complications, pathology*, surgery Humans Magnetic Resonance Imaging Male Middle Aged Optic Nerve / pathology* Recovery of Function Retina / pathology Vision, Low / pathology* von Hippel-Lindau Disease / complications, pathology*, surgery |
| Grant Support | |
ID/Acronym/Agency:
|
Z01 NS003053-01/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Proton magnetic resonance spectroscopy in pituitary macroadenomas: preliminary results.
Next Document: Multiple fusiform myxomatous cerebral aneurysms in a patient with Carney complex.