Document Detail

Progressive osseous heteroplasia, uncommon cause of soft tissue ossification: a case report and review of the literature.
MedLine Citation:
PMID:  8597867     Owner:  NLM     Status:  MEDLINE    
We report a case of an uncommon, recently described disease manifesting shortly after birth, characterized by extensive soft tissue calcification with ossification, progressive osseous heteroplasia. We describe the complex histopathologic patterns present in this case, discuss the main differential diagnoses that the surgical pathologist must consider when confronted by soft tissue ossification, and review the pertinent literature. We conclude that although the morphologic patterns of ossification in progressive osseous heteroplasia are complex and the involvement is extensive, the morphology of the lesions lacks diagnostic specificity. The diagnosis must be based on a consideration of the combined clinical data and radiologic and pathologic findings. This approach alone makes it possible to exclude a number of clinicopathologic entities that manifest with so-called osteoma cutis but whose associated lesions and genetic implications are different.
R Rodriguez-Jurado; F Gonzalez-Crussi; A K Poznanski
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association     Volume:  15     ISSN:  1077-1042     ISO Abbreviation:  Pediatr Pathol Lab Med     Publication Date:    1995 Sep-Oct
Date Detail:
Created Date:  1996-04-22     Completed Date:  1996-04-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9518033     Medline TA:  Pediatr Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  813-27     Citation Subset:  IM    
Department of Pathology, Children's Memorial Hospital, Chicago, Illinois 60614, USA.
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MeSH Terms
Calcinosis / diagnosis,  pathology*
Child, Preschool
Diagnosis, Differential
Myositis Ossificans / diagnosis
Ossification, Heterotopic / diagnosis,  pathology*

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