Document Detail

Progressive nature of paroxysmal atrial fibrillation. Observations from a 14-year follow-up study.
MedLine Citation:
PMID:  15170094     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Atrial fibrillation (AF) is believed to occur first as paroxysmal, then be gradually perpetuated, and finally become chronic as the end result. However, this presumed clinical course has not been well confirmed. METHODS AND RESULTS: The clinical course of recurrent paroxysmal AF (PAF) from its onset was examined in 171 patients (mean follow-up period: 14.1+/-8.1 years). This study population consisted of patients with no structural heart disease (n=88), ischemic heart disease (n=28), dilated or hypertrophic cardiomyopathy (n=17), valvular heart disease (n=35) or other cardiac diseases. The mean age at the onset of AF was 58.3 +/-11.8 years old. During the mean follow-up period of 14.1 years, PAF eventually developed into its chronic form in 132 patients under conventional antiarrhythmic therapy (77.2%, 5.5% of patients per year). The independent factors for early development into chronic AF were aging (hazard ratio (HR) 1.27 per 10 years, 95% confidence interval (CI) 1.06-1.47)), dilated left atrium (HR 1.39 per 10 mm, 95% CI 1.11-1.69), myocardial infarction (HR 2.33, 95% CI 1.13-4.81), and valvular diseases (HR 2.29, 95% CI 1.22-4.30). CONCLUSIONS: The present long-term observations definitely and quantitatively revealed the progressive nature of PAF.
Takeshi Kato; Takeshi Yamashita; Kouichi Sagara; Hiroyuki Iinuma; Long-Tai Fu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  68     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-31     Completed Date:  2005-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  568-72     Citation Subset:  IM    
The Cardiovascular Institute, Tokyo, Japan.
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MeSH Terms
Age of Onset
Anti-Arrhythmia Agents / therapeutic use
Atrial Fibrillation / epidemiology*,  pathology*
Chronic Disease
Data Collection
Disease Progression
Follow-Up Studies
Heart Atria / pathology
Heart Valve Diseases / epidemiology
Middle Aged
Myocardial Infarction / epidemiology
Odds Ratio
Retrospective Studies
Tachycardia, Paroxysmal
Reg. No./Substance:
0/Anti-Arrhythmia Agents

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