| Progressive myopathy with circulating autoantibody against giantin in the Golgi apparatus. | |
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MedLine Citation:
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PMID: 15159505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A woman aged 59 years with adult-onset progressive myopathy had anti-Golgi (giantin) autoantibody in the serum. Limb-muscle biopsy revealed chronic myopathy with paucity of cellular reactions and reduced immunostaining for alpha-dystroglycan. The similarity of the current patient with cases of hereditary alpha-dystroglycanopathies (Fukuyama-type congenital muscular dystrophy, Walker-Warburg syndrome, muscle-eye-brain disease, congenital muscular dystrophy type 1C, and limb-girdle muscular dystrophy type 2I) suggests that the Golgi apparatus is the target organelle in a subset of myopathies. |
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Authors:
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K Sahashi; T Ibi; K Ohno; K Sahashi; N Nakao; H Kondo |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 62 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-25 Completed Date: 2004-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 1891-3 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Aichi Medical University, Japan. sahashi@amugw.aichi-med-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibody Specificity Autoantibodies / blood, immunology* Autoantigens / immunology* Autoimmune Diseases / blood, immunology*, pathology Disease Progression Female Golgi Apparatus / chemistry Humans Middle Aged Muscle, Skeletal / immunology, pathology Muscular Disorders, Atrophic / blood, immunology*, pathology Ribonucleases / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Autoantigens; EC 3.1.-/Ribonucleases; EC 3.1.-/gigantin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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