| Progressive multifocal leukoencephalopathy with concurrent Richter's syndrome. | |
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MedLine Citation:
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PMID: 10811461 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Progressive multifocal leukoencephalopathy (PML) is a demyelinating infectious disease caused by the JC virus. It was originally described in patients with chronic lymphocytic leukemia (CLL). Richter's syndrome, or transformation to large cell Lymphoma, occurs in approximately 3% of patients with CLL, and carries a poor prognosis. We report a patient with documented PML and concurrent Richter's transformation outside the central nervous system. Before establishing a definitive diagnosis of PML, radiation therapy to the presumed lymphomatous brain lesion had been considered, raising the issue of whether stereotactic brain biopsy should be considered in every patient in a similar situation. Although this is likely a rare occurrence, patients with Richter's transformation documented at an extra-neural site and a brain lesion may benefit from the establishment of an infectious diagnosis which would influence therapy. |
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Authors:
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E D Saad; D A Thomas; S O'Brien; G N Fuller; L J Medeiros; A Forman; M Albitar; D Schomer; H M Kantarjian; M J Keating |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 38 ISSN: 1042-8194 ISO Abbreviation: Leuk. Lymphoma Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-07-24 Completed Date: 2000-07-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 183-90 Citation Subset: IM |
Affiliation:
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Department of Leukemia, at the University of Texas M.D. Anderson Cancer Center Houston, 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Transformation, Neoplastic Humans JC Virus / isolation & purification Leukemia, Lymphocytic, Chronic, B-Cell / complications*, pathology Leukoencephalopathy, Progressive Multifocal / complications*, pathology, virology Lymphoma, Large B-Cell, Diffuse / etiology*, pathology Male Middle Aged |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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