Document Detail

Progressive multifocal leukoencephalopathy with concurrent Richter's syndrome.
MedLine Citation:
PMID:  10811461     Owner:  NLM     Status:  MEDLINE    
Progressive multifocal leukoencephalopathy (PML) is a demyelinating infectious disease caused by the JC virus. It was originally described in patients with chronic lymphocytic leukemia (CLL). Richter's syndrome, or transformation to large cell Lymphoma, occurs in approximately 3% of patients with CLL, and carries a poor prognosis. We report a patient with documented PML and concurrent Richter's transformation outside the central nervous system. Before establishing a definitive diagnosis of PML, radiation therapy to the presumed lymphomatous brain lesion had been considered, raising the issue of whether stereotactic brain biopsy should be considered in every patient in a similar situation. Although this is likely a rare occurrence, patients with Richter's transformation documented at an extra-neural site and a brain lesion may benefit from the establishment of an infectious diagnosis which would influence therapy.
E D Saad; D A Thomas; S O'Brien; G N Fuller; L J Medeiros; A Forman; M Albitar; D Schomer; H M Kantarjian; M J Keating
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  38     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-24     Completed Date:  2000-07-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  183-90     Citation Subset:  IM    
Department of Leukemia, at the University of Texas M.D. Anderson Cancer Center Houston, 77030, USA.
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MeSH Terms
Cell Transformation, Neoplastic
JC Virus / isolation & purification
Leukemia, Lymphocytic, Chronic, B-Cell / complications*,  pathology
Leukoencephalopathy, Progressive Multifocal / complications*,  pathology,  virology
Lymphoma, Large B-Cell, Diffuse / etiology*,  pathology
Middle Aged

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