| Progressive multifocal leukoencephalopathy in a patient treated with etanercept. | |
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MedLine Citation:
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PMID: 22367837 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: : Recently, increased attention has been paid to the association of progressive multifocal leukoencephalopathy (PML) with the use of immunomodulatory medications for autoimmune diseases. CASE REPORT: : A 23-year-old Native American woman with a history of systemic lupus erythematosus and erosive polyarthritis treated with prednisone and etanercept presented with focal weakness, hemiataxia, diplopia, and dysarthria. Brain magnetic resonance imaging demonstrated progressive, T2 signal hyperintensities within the brainstem and cerebellar white matter without mass effect or gadolinium enhancement. Cerebrospinal fluid showed elevated protein and JC virus polymerase chain reaction positive with 28,600 copies/ml diagnostic of PML. CONCLUSIONS: : The development of PML in this patient treated with etanercept and prednisone highlights the increased risk for opportunistic infection with JC virus in patients with autoimmune diseases on immunosuppressive therapies. |
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Authors:
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Jonathan Graff-Radford; Maisha T Robinson; Rahma M Warsame; Eric L Matteson; Scott D Z Eggers; B Mark Keegan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The neurologist Volume: 18 ISSN: 1074-7931 ISO Abbreviation: Neurologist Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503763 Medline TA: Neurologist Country: United States |
Other Details:
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Languages: eng Pagination: 85-7 Citation Subset: IM |
Affiliation:
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Departments of *Neurology †Internal Medicine, Mayo Clinic, Rochester, MN. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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