Document Detail

Progressive multifocal leukoencephalopathy in a patient with multiple myeloma.
MedLine Citation:
PMID:  20506049     Owner:  NLM     Status:  MEDLINE    
Progressive multifocal leukoencephalopathy (PML) is a neurological disease that affects immunodeficient patients. We describe here a case of 64-year-old man with IgD type multiple myeloma (MM) who developed progressive neurological symptoms. T(2)-weighted magnetic resonance imaging of the brain showed a hyperintense non-enhancing lesion in the left frontal lobe, and analysis of the cerebrospinal fluid by polymerase chain reaction revealed the presence of John Cunningham virus (JCV) DNA. Histopathological analysis of the autopsy brain specimen with in situ hybridization assay revealed the presence of JCV DNA in the nuclei of oligodendroglia. PML in a patient with MM is rare. However, this case report suggests that PML should be suspected and relevant diagnostic examinations should be performed when MM patients present with neurological symptoms.
Masaru Akiyama; Toru Takahashi; Sinjo Nomura; Yoshimi Yamashita; Katsuhiro Hatao
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-05-28
Journal Detail:
Title:  International journal of hematology     Volume:  92     ISSN:  1865-3774     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  186-9     Citation Subset:  IM    
Department of Hematology, Tokuyama Central Hospital, 1-1 Koda, Shunan, Yamaguchi, Japan.
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MeSH Terms
Brain / pathology,  virology
Cerebrospinal Fluid / virology
JC Virus / isolation & purification
Leukoencephalopathy, Progressive Multifocal / diagnosis*
Magnetic Resonance Imaging
Middle Aged
Multiple Myeloma / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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