| Progressive multifocal leukoencephalopathy in a patient with multiple myeloma. | |
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MedLine Citation:
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PMID: 20506049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Progressive multifocal leukoencephalopathy (PML) is a neurological disease that affects immunodeficient patients. We describe here a case of 64-year-old man with IgD type multiple myeloma (MM) who developed progressive neurological symptoms. T(2)-weighted magnetic resonance imaging of the brain showed a hyperintense non-enhancing lesion in the left frontal lobe, and analysis of the cerebrospinal fluid by polymerase chain reaction revealed the presence of John Cunningham virus (JCV) DNA. Histopathological analysis of the autopsy brain specimen with in situ hybridization assay revealed the presence of JCV DNA in the nuclei of oligodendroglia. PML in a patient with MM is rare. However, this case report suggests that PML should be suspected and relevant diagnostic examinations should be performed when MM patients present with neurological symptoms. |
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Authors:
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Masaru Akiyama; Toru Takahashi; Sinjo Nomura; Yoshimi Yamashita; Katsuhiro Hatao |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-05-28 |
Journal Detail:
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Title: International journal of hematology Volume: 92 ISSN: 1865-3774 ISO Abbreviation: Int. J. Hematol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 186-9 Citation Subset: IM |
Affiliation:
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Department of Hematology, Tokuyama Central Hospital, 1-1 Koda, Shunan, Yamaguchi, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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pathology,
virology Cerebrospinal Fluid / virology Humans JC Virus / isolation & purification Leukoencephalopathy, Progressive Multifocal / diagnosis* Magnetic Resonance Imaging Male Middle Aged Multiple Myeloma / complications* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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