Document Detail

Progressive multifocal leukoencephalopathy in a patient with Good's syndrome.
MedLine Citation:
PMID:  19695918     Owner:  NLM     Status:  MEDLINE    
Good's syndrome (GS) is an immunodeficiency characterized by thymoma, hypogammaglobulinemia, and impaired T-cell function. The clinical manifestations of GS include recurrent or chronic infections from common or opportunistic pathogens. Encephalitis is a rare event, with only anecdotal reports of cytomegalovirus infection. Herein we report the case of a 79-year-old woman with GS who developed subacute motor deficits and cognitive changes. Magnetic resonance imaging (MRI) of the brain disclosed white- and gray-matter lesions, mostly in the right frontal and parietal areas. Polyoma virus JC, the agent of progressive multifocal encephalopathy (PML), was identified in cerebrospinal fluid samples and brain biopsy specimens. After diagnosis, the disease had a rapid fatal course. The present case represents the first reported association between GS and PML.
Giovanna Squintani; Sergio Ferrari; Elena Bazzoli; Roberto Eleopra; Carlo La Monaca; Enrico Cagliari; Gianluigi Zanusso; Maria Cristina Mantovan; Salvatore Monaco
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-08-19
Journal Detail:
Title:  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases     Volume:  14     ISSN:  1878-3511     ISO Abbreviation:  Int. J. Infect. Dis.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-08-02     Revised Date:  2010-10-22    
Medline Journal Info:
Nlm Unique ID:  9610933     Medline TA:  Int J Infect Dis     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  e444-7     Citation Subset:  IM    
Copyright Information:
Copyright 2009 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Neurology Unit, Ospedale Civile Maggiore, Piazzale Stefani, 1, 37134, Verona, Italy.
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MeSH Terms
Brain / pathology
Fatal Outcome
Immunologic Deficiency Syndromes / complications*,  pathology
JC Virus / isolation & purification*
Leukoencephalopathy, Progressive Multifocal / complications*,  pathology,  virology
Comment In:
Int J Infect Dis. 2010 Sep;14 Suppl 3:e367-8   [PMID:  20561807 ]

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