| Progressive multifocal leukoencephalopathy in chronic lymphocytic leukemia: a report of three cases and review of the literature. | |
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MedLine Citation:
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PMID: 20223720 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the John Cunningham (JC) virus, a DNA papovavirus. It is usually associated with conditions causing profound immunodeficiency, classically seen in patients with HIV/AIDS. Since its first description in 1958, PML has also been associated with various lymphoproliferative malignancies, including chronic lymphocytic leukemia (CLL). With the use of newer chemotherapeutic agents such as the purine analogue fludarabine and various monoclonal antibodies in the treatment of CLL, more cases of PML are being described. In this article, we describe 3 patients encountered in our clinical practice having CLL and PML infection. All three patients had received fludarabine and rituximab at some point during the course of their chemotherapy. We provide these cases with a review of the literature. |
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Authors:
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Anita D'Souza; Jon Wilson; Sudipto Mukherjee; Ishmael Jaiyesimi |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Clinical lymphoma, myeloma & leukemia Volume: 10 ISSN: 2152-2669 ISO Abbreviation: Clin Lymphoma Myeloma Leuk Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-12 Completed Date: 2010-06-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101525386 Medline TA: Clin Lymphoma Myeloma Leuk Country: United States |
Other Details:
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Languages: eng Pagination: E1-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, William Beaumont Hospital, Royal Oak, MI 48017, USA. anita.dsouza@beaumont.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antibodies, Monoclonal / adverse effects Hematopoietic Stem Cell Transplantation / adverse effects Humans Leukemia, Lymphocytic, Chronic, B-Cell / complications Leukoencephalopathy, Progressive Multifocal / etiology*, pathology Magnetic Resonance Imaging Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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