| Progressive multifocal leukoencephalopathy developed in incomplete Heerfordt syndrome, a rare manifestation of sarcoidosis, without steroid therapy responding to cidofovir. | |
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MedLine Citation:
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PMID: 19892460 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by the JC virus; the mortality rate is high and it is usually refractory to treatment. In non-HIV patients, PML occurs as a late consequence of hematologic malignancies or during prolonged immunosuppression for transplantation or autoimmune disease. We describe a 34-year-old PML patient with incomplete Heerfordt syndrome, a rare type of sarcoidosis, who had not received any immunosuppressants, including steroids, at the onset and who was clinically and radiologically responsive to the antiviral drug cidofovir. |
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Authors:
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Takuya Yagi; Hidenori Hattori; Masayuki Ohira; Kazuo Nakamichi; Mutsuyo Takayama-Ito; Masayuki Saijo; Toshihiko Shimizu; Daisuke Ito; Kazushi Takahashi; Norihiro Suzuki |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-11-04 |
Journal Detail:
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Title: Clinical neurology and neurosurgery Volume: 112 ISSN: 1872-6968 ISO Abbreviation: Clin Neurol Neurosurg Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502039 Medline TA: Clin Neurol Neurosurg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 153-6 Citation Subset: IM |
Copyright Information:
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2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Neurology, Keio University School of Medicine, Tokyo, Japan. takuyagi@z7.keio.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antiviral Agents / therapeutic use* Cytosine / analogs & derivatives*, therapeutic use Humans Leukoencephalopathy, Progressive Multifocal / etiology*, radiography Male Parotid Gland / radiography Phosphonic Acids / therapeutic use* Sarcoidosis / drug therapy*, radiography Treatment Outcome Uveoparotid Fever / complications*, radiography |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Phosphonic Acids; 113852-37-2/cidofovir; 71-30-7/Cytosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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