Document Detail


Progressive multifocal leukoencephalopathy as the first manifestation of occult sarcoidosis: case report and review of the literature.
MedLine Citation:
PMID:  23269104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Progressive multifocal leukoencephalopathy (PML), a demyelinating disease of the central nervous system, is caused by reactivation of the JC virus. This disease is typically seen in individuals with known immune suppression. It has also been associated with other inflammatory conditions, such as sarcoidosis.
CASE REPORT: A 68-year-old woman without known immune suppression presented with mental status changes over several weeks. Brain biopsy and cerebrospinal fluid analysis led to the diagnosis of PML. On autopsy, she was found to have previously undiagnosed sarcoidosis.
CONCLUSIONS: To our knowledge, this is the first published case of PML as the first manifestation of sarcoidosis in the absence of inflammatory hematologic involvement.
Authors:
Matthew J Davis; Adnan Khan; Walter Royal
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The neurologist     Volume:  19     ISSN:  1074-7931     ISO Abbreviation:  Neurologist     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-27     Completed Date:  2013-06-07     Revised Date:  2013-06-21    
Medline Journal Info:
Nlm Unique ID:  9503763     Medline TA:  Neurologist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  26-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Maryland Medical Center, Baltimore, MD 21201, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antigens, CD / metabolism
Antigens, Differentiation, Myelomonocytic / metabolism
Autopsy
Choline / metabolism
Creatine / metabolism
Female
Humans
Leukoencephalopathy, Progressive Multifocal / complications*
Lung / pathology
Lymph Nodes / pathology
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Myocardium / pathology
Occipital Lobe / metabolism,  pathology
Ocular Motility Disorders* / complications,  diagnosis,  etiology
Oligopeptides / metabolism
Sarcoidosis* / complications,  diagnosis,  etiology
Temporal Lobe / metabolism,  pathology
Grant Support
ID/Acronym/Agency:
R01 DA021556/DA/NIDA NIH HHS; R01 MH086356/MH/NIMH NIH HHS; R21 NS070708/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 0/Oligopeptides; 0/SV40 nuclear localization peptide; 57-00-1/Creatine; 62-49-7/Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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