| Progressive multifocal leukoencephalopathy after stem cell transplantation, unsuccessfully treated with cidofovir. | |
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MedLine Citation:
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PMID: 12476291 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a patient with progressive multifocal leukoencephalopathy (PML) after autologous stem cell transplantation (SCT) for non-Hodgkin's lymphoma (NHL). This is an unusual association, and to date only seven cases have been reported. This is the first case of PML after SCT treated with cidofovir, and the fifth case treated with this drug in a patient without human immunodeficiency virus (HIV) infection. In the previous four patients treated with cidofovir the outcome was discouraging, as was the case in this patient. |
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Authors:
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S Osorio; R de la Cámara; N Golbano; E Marti; C G Fedele; S Nieto; R Manzanares; J M Fernández-Rañada |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Bone marrow transplantation Volume: 30 ISSN: 0268-3369 ISO Abbreviation: Bone Marrow Transplant. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-11 Completed Date: 2003-07-31 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 8702459 Medline TA: Bone Marrow Transplant Country: England |
Other Details:
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Languages: eng Pagination: 963-6 Citation Subset: IM |
Affiliation:
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Department of Hematology, Hospital de la Princesa, Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use Antiviral Agents / therapeutic use* Brain / virology Combined Modality Therapy Cytosine / analogs & derivatives*, therapeutic use* Fatal Outcome HIV Seronegativity Humans Immunocompromised Host JC Virus / isolation & purification Leukoencephalopathy, Progressive Multifocal / drug therapy*, etiology, virology Lymphoma, Mantle-Cell / complications, drug therapy, therapy Magnetic Resonance Imaging Male Middle Aged Organophosphorus Compounds / therapeutic use* Peripheral Blood Stem Cell Transplantation / adverse effects* Phosphonic Acids* Transplantation, Autologous / adverse effects Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Organophosphorus Compounds; 0/Phosphonic Acids; 113852-37-2/cidofovir; 71-30-7/Cytosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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