Document Detail


Progressive multifocal leukoencephalopathy after stem cell transplantation, unsuccessfully treated with cidofovir.
MedLine Citation:
PMID:  12476291     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a patient with progressive multifocal leukoencephalopathy (PML) after autologous stem cell transplantation (SCT) for non-Hodgkin's lymphoma (NHL). This is an unusual association, and to date only seven cases have been reported. This is the first case of PML after SCT treated with cidofovir, and the fifth case treated with this drug in a patient without human immunodeficiency virus (HIV) infection. In the previous four patients treated with cidofovir the outcome was discouraging, as was the case in this patient.
Authors:
S Osorio; R de la Cámara; N Golbano; E Marti; C G Fedele; S Nieto; R Manzanares; J M Fernández-Rañada
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  30     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-11     Completed Date:  2003-07-31     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  963-6     Citation Subset:  IM    
Affiliation:
Department of Hematology, Hospital de la Princesa, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Antiviral Agents / therapeutic use*
Brain / virology
Combined Modality Therapy
Cytosine / analogs & derivatives*,  therapeutic use*
Fatal Outcome
HIV Seronegativity
Humans
Immunocompromised Host
JC Virus / isolation & purification
Leukoencephalopathy, Progressive Multifocal / drug therapy*,  etiology,  virology
Lymphoma, Mantle-Cell / complications,  drug therapy,  therapy
Magnetic Resonance Imaging
Male
Middle Aged
Organophosphonates*
Organophosphorus Compounds / therapeutic use*
Peripheral Blood Stem Cell Transplantation / adverse effects*
Transplantation, Autologous / adverse effects
Treatment Failure
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Organophosphonates; 0/Organophosphorus Compounds; 71-30-7/Cytosine; JIL713Q00N/cidofovir

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