| Progressive multifocal leucoencephalopathy in an immunocompetent patient with favourable outcome. A case report. | |
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MedLine Citation:
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PMID: 20482768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To report the clinical course of PML in an apparently immunocompetent patient treated with cidofovir. CASE PRESENTATION: A 35-year-old immunocompetent man who developed progressive hemianopsia, aphasia, and limb weakness underwent repeated MRI scans of the brain, spinal fluid analyses, and brain biopsy. Before diagnosis was established based on brain biopsy, he was consecutively treated with methylprednisolone, acyclovir, ceftriaxone and plasmapheresis, but he deteriorated rapidly suggestive of the immune reconstitution inflammatory syndrome (IRIS). He started to recover two weeks after the initiation of treatment with cidofovir and has had no relapse at 3 1/2 years of follow-up. MRI has shown marked improvement. CONCLUSIONS: PML should be considered in immunocompetent patients with a typical clinical course and MRI findings compatible with PML. Treatment with cidofovir should be considered as early as possible in the disease course. |
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Authors:
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Halvor Naess; Solveig Glad; Anette Storstein; Christine H Rinaldo; Sverre J Mørk; Kjell-Morten Myhr; Hans Hirsch |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-05-18 |
Journal Detail:
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Title: BMC neurology Volume: 10 ISSN: 1471-2377 ISO Abbreviation: BMC Neurol Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-07 Completed Date: 2010-07-12 Revised Date: 2010-09-30 |
Medline Journal Info:
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Nlm Unique ID: 100968555 Medline TA: BMC Neurol Country: England |
Other Details:
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Languages: eng Pagination: 32 Citation Subset: IM |
Affiliation:
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Department of Neurology, Haukeland University Hospital, N-5021 Bergen, Norway. haln@haukeland.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Humans Immunocompetence / physiology* Leukoencephalopathy, Progressive Multifocal / diagnosis*, physiopathology* Magnetic Resonance Imaging / methods Male |
| Comments/Corrections | |
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