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Progressive left ventricular noncompaction and systolic dysfunction.
MedLine Citation:
PMID:  22826654     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Left ventricular noncompaction is a condition characterized by prominent ventricular trabeculations, often accompanied by systolic dysfunction. The present case involves an adult with a small ventricular septal defect, initially exhibiting mild systolic dysfunction and slightly prominent left ventricular trabeculations progressing over 13 years to severe dilated cardiomyopathy and overt noncompaction. The present case strongly suggests a correlation between the extent of noncompaction and the degree of systolic dysfunction. The initial presence of a small ventricular septal defect and mild trabeculations highlights the genetic determinants of non-compaction and the importance of closely following patients with mild noncompaction due to the possibility of progression. More sensitive diagnostic criteria are needed to avoid overlooking mild cases, which may show prominent trabeculations without reaching a requisite ratio of compacted to noncompacted tissue.
Authors:
Irene M Hutchins; Saul Schaefer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental and clinical cardiology     Volume:  17     ISSN:  1918-1515     ISO Abbreviation:  Exp Clin Cardiol     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-24     Completed Date:  2012-08-23     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  9715903     Medline TA:  Exp Clin Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  81-3     Citation Subset:  -    
Affiliation:
Department of Internal Medicine, University of California, Davis, Davis, California, USA.
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