| Progressive language disorder due to lobar atrophy. | |
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MedLine Citation:
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PMID: 1575456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sixteen patients with progressive language disorder have been studied longitudinally. Anomia was a prominent presenting characteristic and mutism ultimately occurred. Patients, however, were clinically heterogeneous. Some exhibited nonfluent, agrammatic features, whereas others demonstrated a fluent aphasia, with profound loss of word meaning. Although language disorder remained the sole symptom in a minority of patients, in others an associative agnosia or personality and behavioral changes, or both, emerged. Findings on computed tomography and single photon emission tomography mirrored the areas of dysfunction suggested by the neuropsychological profiles and demonstrated abnormalities restricted to the left hemisphere or involving bilateral frontotemporal cortices. Brains of 3 patients, with distinctive clinical pictures, have been examined at autopsy. Each revealed a focal distribution of atrophy, gliosis and spongiform change, and an absence of senile plaques and neurofibrillary tangles. There was clinical and pathological overlap with frontal lobe dementia. We argue that progressive language disorder is clinically heterogeneous and forms part of a spectrum of clinical presentations of non-Alzheimer lobar atrophy. |
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Authors:
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J S Snowden; D Neary; D M Mann; P J Goulding; H J Testa |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Annals of neurology Volume: 31 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-06-01 Completed Date: 1992-06-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 174-83 Citation Subset: IM |
Affiliation:
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Department of Neurology, Manchester Royal Infirmary, England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Agnosia / pathology, radionuclide imaging Alzheimer Disease / pathology Anomia / pathology, radionuclide imaging Aphasia, Wernicke / pathology, radionuclide imaging Atrophy Dementia / pathology Female Frontal Lobe / pathology*, radionuclide imaging Gliosis Humans Language Disorders / pathology*, radionuclide imaging Male Middle Aged Neuropsychological Tests Temporal Lobe / pathology*, radionuclide imaging Tomography, Emission-Computed, Single-Photon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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