Document Detail


Progressive increase of human papillomavirus carriage rates in potentially malignant and malignant oral disorders with increasing malignant potential.
MedLine Citation:
PMID:  19572894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: We investigated the potential role of human papillomaviruses (HPVs) in potentially malignant oral disorders, oral leukoplakia (OL) and oral lichen planus (OLP), and in oral squamous cell cancer (OSCC) in an Eastern Hungarian population with a high incidence of OSCC. METHODS: Excised tumor samples (65 OSCC patients) and exfoliated cells from potentially malignant lesions (from 44 and 119 patients with OL and OLP, respectively) as well as from healthy controls (72 individuals) were analysed. OLPs were classified based on clinical appearance, 61 patients had erosive-atrophic lesions (associated with higher malignancy risk, EA-OLP) and 58 had non-erosive non-atrophic lesions (with lower risk of becoming malignant, non-EA-OLP), respectively. Exfoliated cells collected from apparently healthy mucosa accompanied each lesion sample. HPV was detected by MY/GP polymerase chain reaction (PCR) and genotyped by restriction analysis of amplimers. Copy numbers in lesions were determined using real-time PCR. Prevalence rates, copy number distributions, and association with risk factors and diseases were analysed using chi-square test, t-test, and logistic regression, respectively. RESULTS: We detected HPVs significantly more frequently in lesions than in controls (P < or = 0.001 in all comparisons). HPV prevalence increased gradually with increasing severity of lesions (32.8, 40.9, and 47.7% in OLP, OL, and OSCC, respectively). Copy number distribution patterns roughly corresponded to prevalence rates, but OLP and OL were comparable. HPV prevalence differed significantly between EA-OLP and non-EA-OLP groups (42.6 vs. 22.4%); EA-OLP group showed a prevalence similar to that found in OL. CONCLUSION: HPVs may be involved in the development or progression of not only OSCC but also of potentially malignant oral lesions.
Authors:
K Szarka; I Tar; E Fehér; T Gáll; A Kis; E D Tóth; R Boda; I Márton; L Gergely
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oral microbiology and immunology     Volume:  24     ISSN:  1399-302X     ISO Abbreviation:  Oral Microbiol. Immunol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-03     Completed Date:  2009-10-05     Revised Date:  2010-09-03    
Medline Journal Info:
Nlm Unique ID:  8707451     Medline TA:  Oral Microbiol Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  314-8     Citation Subset:  D    
Affiliation:
Department of Medical Microbiology, Medical and Health Science Center, University of Debrecen, H-4032 Debrecen, Nagyerdei krt. 98, Hungary. szkrisz@med.unideb.hu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell / virology*
Case-Control Studies
Cell Transformation, Neoplastic
Female
Humans
Hungary
Leukoplakia, Oral / virology*
Lichen Planus, Oral / virology*
Logistic Models
Male
Middle Aged
Mouth Mucosa / virology*
Mouth Neoplasms / virology*
Papillomaviridae / isolation & purification*
Polymerase Chain Reaction / methods
Risk Factors
Young Adult
Comments/Corrections
Comment In:
J Evid Based Dent Pract. 2010 Sep;10(3):174-5   [PMID:  20797668 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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