Document Detail


Progressive immune dysfunction in cats experimentally infected with feline immunodeficiency virus.
MedLine Citation:
PMID:  1673159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Within 6 months of infection with the Petaluma isolate of feline immunodeficiency virus, specific-pathogen-free domestic cats exhibited a decrease in the percentage and number of circulating CD4+ lymphocytes and in the CD4+/CD8+ T-cell ratio, along with a marginally significant depression of pokeweed mitogen-induced lymphocyte proliferation in vitro. There was no loss of responsiveness to concanavalin A during this stage, and the cats were capable of mounting a satisfactory antibody response to a T-dependent, synthetic polypeptide immunogen. The pokeweed mitogen response deficit became clearly demonstrable by 11 to 12 months postinfection. A decline in the lymphocyte proliferative response to concanavalin A and a diminished ability to mount an in vivo antibody response to the T-dependent immunogen evolved by 25 to 44 months postinfection. Virus infection did not affect the ability of cats to mount an antibody response to a T-independent synthetic polypeptide immunogen. These data indicate that feline immunodeficiency virus produces a slowly progressive deterioration of T-cell function but does not affect the ability of B cells to recognize and respond to a T-independent antigenic stimulus.
Authors:
M Torten; M Franchini; J E Barlough; J W George; E Mozes; H Lutz; N C Pedersen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of virology     Volume:  65     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-05-20     Completed Date:  1991-05-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2225-30     Citation Subset:  IM; X    
Affiliation:
Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Antibodies, Viral / biosynthesis
Antigens, CD4
Antigens, CD8
Antigens, Differentiation, T-Lymphocyte
CD4-Positive T-Lymphocytes / immunology
Cats
Concanavalin A / pharmacology
Enzyme-Linked Immunosorbent Assay
Feline Acquired Immunodeficiency Syndrome / immunology*,  physiopathology
Immunodeficiency Virus, Feline / immunology
Molecular Sequence Data
Peptides / chemical synthesis,  immunology
Pokeweed Mitogens / pharmacology
Specific Pathogen-Free Organisms
T-Lymphocytes, Regulatory / immunology
Grant Support
ID/Acronym/Agency:
AI-25802-03/AI/NIAID NIH HHS; CA-50179-01/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Antigens, CD4; 0/Antigens, CD8; 0/Antigens, Differentiation, T-Lymphocyte; 0/Peptides; 0/Pokeweed Mitogens; 11028-71-0/Concanavalin A
Comments/Corrections

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