Document Detail


Progressive expansion of an L-selectin-negative CD8 cell with anti-feline immunodeficiency virus (FIV) suppressor function in the circulation of FIV-infected cats.
MedLine Citation:
PMID:  10515809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The acute stage of feline immunodeficiency virus (FIV) infection is characterized by the appearance of a major CD8 subpopulation with reduced expression of the CD8 beta chain (CD8alpha+betalo). CD8 antiviral activity was subsequently shown to be mediated by the CD8alpha+betalo phenotype, which is the dominant CD8 phenotype in long-term infected cats. Two- and three-color flow cytometric analysis demonstrated that the CD8alpha+betalo subset is L-selectin negative (CD62L-) and has increased expression of CD44, CD49d, and CD18, consistent with an activation phenotype. The CD8alpha+betaloCD62L- cells but not the CD8alpha+betahiCD62L+ cells demonstrated strong antiviral activity in the FIV acute-infection assay. The progressive expansion of the CD8alpha+betaloCD62L- effector subset cells in FIV-infected cats parallels that seen in human immunodeficiency virus (HIV)-infected patients, suggesting that failure in homeostatic mechanisms regulating lymphocyte activation or trafficking (or both) may be a consequence of both HIV and FIV infections.
Authors:
D H Gebhard; J L Dow; T A Childers; J I Alvelo; M B Tompkins; W A Tompkins
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  180     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-09     Completed Date:  1999-12-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1503-13     Citation Subset:  AIM; IM; X    
Affiliation:
Department of Microbiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
CD8-Positive T-Lymphocytes / immunology*
Cats
Feline Acquired Immunodeficiency Syndrome / immunology*
Immunodeficiency Virus, Feline / immunology*
Immunophenotyping
Integrins / metabolism
L-Selectin / analysis*
Leukocytes, Mononuclear / immunology
Lymph Nodes / immunology
T-Lymphocyte Subsets / immunology*
T-Lymphocytes, Regulatory / immunology*
Grant Support
ID/Acronym/Agency:
AI-38177/AI/NIAID NIH HHS; AI-43858/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Integrins; 126880-86-2/L-Selectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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