Document Detail

Progressive dystonia and paraparesis in cerebral palsy.
MedLine Citation:
PMID:  3948889     Owner:  NLM     Status:  MEDLINE    
Cerebral palsy (CP) was commonly considered as a static encephalopathy with various clinical forms. Among them the dystonic form may occur alone (15%) or combined with other manifestations (e.g. spasticity). In a country-wide survey of dystonia in Israel, we discovered 7 cases in whom dystonia and/or spastic paraparesis appeared or worsened on the background of CP. The clinical deterioration occurred between 14 and 40 years of age and resulted in a bedridden state in 2 of the 7 patients. The occurrence of extrapyramidal features and/or progressive spastic paraparesis in patients with preexisting CP was not clearly recognized in the literature, although lately some reports suggested 'changing motor patterns' in patients with CP. It is hypothesized that in some cases the pathological substrate, occurring at the perinatal period, may slowly progress in adult life. The fact that the majority of the dystonic subjects were Ashkenazi Jews is reminiscent of the high gene frequency of idiopathic torsion dystonia in this group, and suggests that the genetic tendency may be triggered off by perinatal factors.
T Treves; A D Korczyn
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European neurology     Volume:  25     ISSN:  0014-3022     ISO Abbreviation:  Eur. Neurol.     Publication Date:  1986  
Date Detail:
Created Date:  1986-04-24     Completed Date:  1986-04-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  148-53     Citation Subset:  IM    
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MeSH Terms
Cerebral Palsy / complications*,  epidemiology
Dystonia / complications*,  epidemiology
Paraplegia / complications*,  epidemiology

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