| Progressive depletion of germ cells in a man with nonmosaic Klinefelter's syndrome: optimal time for sperm recovery. | |
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MedLine Citation:
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PMID: 14972499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a sequential deteriorated change of sperm count in a 30-year-old infertile man with nonmosaic Klinefelter's syndrome. His initial semen analysis revealed oligozoospermia; however, the sperm count decreased progressively, which resulted in azoospermia over a period of 3 years. By testicular sperm extraction, a few spermatozoa were recovered. We analyzed the germ cells with three-color fluorescence in situ hybridization, and the presence of a 46,XY lineage was found. We suggest that progressive depletion of germ cells might occur in men with nonmosaic Klinefelter's syndrome and that these men should undergo semen cryopreservation or sperm recovery as early as possible. |
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Authors:
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Yung Ming Lin; William J Huang; Johnny Shinn Nan Lin; Pao Lin Kuo |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Urology Volume: 63 ISSN: 1527-9995 ISO Abbreviation: Urology Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-02-19 Completed Date: 2004-06-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0366151 Medline TA: Urology Country: United States |
Other Details:
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Languages: eng Pagination: 380-1 Citation Subset: IM |
Affiliation:
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Department of Urology, School of Medicine, National Cheng Kung University, Tainan, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Lineage Cryopreservation Disease Progression Humans In Situ Hybridization, Fluorescence Karyotyping Klinefelter Syndrome / complications*, genetics, pathology Male Oligospermia / etiology*, genetics Semen Preservation Sperm Count* Spermatogonia / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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