| Progressive decline in renal function induces a gradual decrease in total hemoglobin and exercise capacity. | |
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MedLine Citation:
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PMID: 7936023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined 58 patients (38 men, 20 women; mean age: 45 +/- 12 years; body mass index: 24 +/- 4 kg/m2) with a glomerular filtration rate (GFR) ranging from 3 to 32 ml/min, in order to determine the effects of a progressive decline in renal function on total hemoglobin (THb) and exercise capacity. The THb ranged from 185 to 759 g and the hemoglobin concentration ranged from 66 to 151 g/l. Maximal exercise capacity ranged from 50 to 260 W (40-143% of the expected norm). Nearly all the patients interrupted their exercise tests due to general fatigue, leg tiredness or a combination of these factors. There was a significant partial correlation between THb and GFR after sex and age had been accounted for (r = 0.39; p < 0.005). Maximal exercise capacity and THb showed a significant partial correlation after sex, age and GFR had been accounted for (r = 0.27; p < 0.05). Maximal exercise capacity showed a significant partial correlation with GFR after sex, age and THb had been accounted for (r = 0.30; P < 0.05). In conclusion, there is a gradual decline in THb and maximal exercise capacity as uremia progresses. Anemia appears to be a contributory cause responsible for the decrease in maximal exercise capacity along with other factors pertinent to uremia per se. |
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Authors:
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N Clyne; T Jogestrand; L E Lins; S K Pehrsson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nephron Volume: 67 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 1994 |
Date Detail:
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Created Date: 1994-10-26 Completed Date: 1994-10-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0331777 Medline TA: Nephron Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 322-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Huddinge Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Anemia / etiology, physiopathology Exercise Tolerance* Female Glomerular Filtration Rate Hemoglobins / analysis* Humans Kidney Failure / complications, physiopathology* Male Middle Aged Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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