| Progressive cerebral atrophy in multiple system atrophy. | |
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MedLine Citation:
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PMID: 11897242 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nine patients with multiple system atrophy (MSA) were studied based on MRI findings of cerebral hemispheric involvement. The age at onset was 56.4+/-8.6 (mean+/-S.D.) years, duration of illness at the first MRI study 2.1+/-1.1 years, duration of illness at the last study 9.7+/-2.6 years, and the follow-up duration 7.6+/-2.3 years. Controls were 85 neurologically intact persons (60.2+/-11.1 years age). In the MRI study, measurements of the ratio of each area to the intracranial area were performed for the cerebral hemisphere, frontal, temporal and parietal-occipital lobes. A significant progression of atrophy to under the normal limit was observed in the cerebrum, frontal and temporal lobes. Besides the typical pathological lesions in MSA, five autopsied patients revealed frontal lobe atrophy with mild gliosis, mild demyelination and glial cytoplasmic inclusions (GCIs). One of these patients showed remarkable frontal lobe atrophy with degenerative changes in the cerebral cortex. We observed the involvement of the cerebral hemisphere, especially the frontal lobe. |
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Authors:
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Masaaki Konagaya; Yoko Konagaya; Motoko Sakai; Yukihiko Matsuoka; Yoshio Hashizume |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 195 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-03-18 Completed Date: 2002-05-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 123-7 Citation Subset: IM |
Affiliation:
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Department of Neurology, Suzuka National Hospital, 3-2-1 Kasado, Mie 513-8501, Suzuka, Japan. konagaya@suzuka.hosp.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age of Onset Aged Basal Ganglia / pathology, physiopathology Cerebellum / pathology, physiopathology Cerebral Cortex / pathology*, physiopathology Disease Progression Female Follow-Up Studies Humans Magnetic Resonance Imaging Male Middle Aged Multiple System Atrophy / pathology*, physiopathology Pons / pathology, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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