Document Detail

Progressive anarthria with secondary parkinsonism: a clinico-pathological case report.
MedLine Citation:
PMID:  1640234     Owner:  NLM     Status:  MEDLINE    
The pathological process and lesion topography in patients with the syndrome of progressive aphasia are heterogeneous and few necropsy examination cases have been investigated. This is a case report of a 53 year old right handed man with progressive anarthria and secondary Parkinsonism over a period of six years. Positron emission tomography (PET) showed a decreased cerebral blood flow and metabolism in the frontal cortex, which was more pronounced on the left. Neuropathology disclosed a spongiform vacuolation in layer II of the frontal cortex, mostly in the Broca area, and neuronal loss in the substantia nigra. This original case reinforces the view that there are different entities of the syndrome of progressive aphasia which can be identified on the basis of clinical, neuroimaging and anatomical data.
E Broussolle; M Tommasi; F Mauguière; G Chazot
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  55     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-09-03     Completed Date:  1992-09-03     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  577-80     Citation Subset:  IM    
Neurometabolic Unit, Antiquaille Hospital, Lyon, France.
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MeSH Terms
Aphonia / pathology,  physiopathology*
Diagnostic Imaging*
Dominance, Cerebral / physiology
Dysarthria / pathology,  physiopathology*
Energy Metabolism / physiology
Frontal Lobe / blood supply,  pathology
Magnetic Resonance Imaging
Middle Aged
Neurologic Examination*
Neuropsychological Tests*
Oxygen Consumption / physiology
Parkinson Disease, Secondary / pathology,  physiopathology*
Regional Blood Flow / physiology
Tomography, Emission-Computed
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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