Document Detail

Progressive alcohol-induced sperm alterations leading to spermatogenic arrest, which was reversed after alcohol withdrawal.
MedLine Citation:
PMID:  20117050     Owner:  NLM     Status:  MEDLINE    
This is a report of a 6-year follow-up of a male patient's semen parameters during heavy chronic alcohol intoxication and after withdrawal. A slowly progressive negative impact of alcohol could be observed: isolated moderate teratozoospermia was firstly noted followed by oligoasthenoteratospermia. Then a severe worsening resulted in cryptozoospermia and ultimately in azoospermia. At this moment, the histological analysis of a testicular biopsy revealed a maturation arrest of the germinal cells at the pachytene stage with no mature sperm cells. Alcohol withdrawal was then obtained, allowing a very fast and drastic improvement of semen characteristics; strictly normal semen parameters were observed after no more than 3 months. Taking into consideration these data, patients should be questioned about their alcohol intake before assisted reproductive technology and should be informed about this adverse effect. Moreover, this case report emphasizes how quickly benefits can be obtained after withdrawal, even in the case of heavy chronic alcohol intake.
Nathalie Sermondade; Hanène Elloumi; Isabelle Berthaut; Emmanuelle Mathieu; Vanina Delarouzière; Célia Ravel; Jacqueline Mandelbaum
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-12-11
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  20     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-26     Completed Date:  2010-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  324-7     Citation Subset:  IM    
Copyright Information:
Copyright 2010. Published by Elsevier Ltd.
Service d'Histologie et Biologie de la Reproduction, Assistance Publique Hôpitaux de Paris (APHP)-Hôpital Tenon, Paris, France.
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MeSH Terms
Alcoholism / complications*,  therapy
Azoospermia / etiology*
Infertility, Male / etiology
Semen Analysis
Spermatogenesis / drug effects*
Substance Withdrawal Syndrome / physiopathology

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