| Progressive handgrip exercise: evidence of nitric oxide-dependent vasodilation and blood flow regulation in humans. | |
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MedLine Citation:
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PMID: 21217074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the peripheral circulation, nitric oxide (NO) is released in response to shear stress across vascular endothelial cells. We sought to assess the degree to which NO contributes to exercise-induced vasodilation in the brachial artery (BA) and to determine the potential of this approach to noninvasively evaluate NO bioavailability. In eight young (25 ± 1 yr) healthy volunteers, we used ultrasound Doppler to examine BA vasodilation in response to handgrip exercise (4, 8, 12, 16, 20, and 24 kg) with and without endothelial NO synthase blockade [intra-arterial N(G)-monomethyl-L-arginine (L-NMMA), 0.48 mg · dl(-1) · min(-1)]. Higher exercise intensities evoked significant BA vasodilation (4-12%) that was positively correlated with the hyperemic stimulus (r = 0.98 ± 0.003, slope = 0.005 ± 0.001). During NO blockade, BA vasodilation at the highest exercise intensity was reduced by ∼70% despite similar exercise-induced increases in shear rate (control, +224 ± 30 s(-1); L-NMMA, +259 ± 46 s(-1)). The relationship and slope of BA vasodilation with increasing shear rate was likewise reduced (r = 0.48 ± 0.1, slope = 0.0007 ± 0.0005). We conclude that endothelial NO synthase inhibition with L-NMMA abolishes the relationship between shear stress and BA vasodilation during handgrip exercise, providing clear evidence of NO-dependent vasodilation in this experimental model. These results support this paradigm as a novel and valid approach for a noninvasive assessment of NO-dependent vasodilation in humans. |
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Authors:
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D Walter Wray; Melissa A H Witman; Stephen J Ives; John McDaniel; Anette S Fjeldstad; Joel D Trinity; Jamie D Conklin; Mark A Supiano; Russell S Richardson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2011-01-07 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 300 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-03 Completed Date: 2011-05-26 Revised Date: 2012-03-01 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1101-7 Citation Subset: IM |
Affiliation:
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Division of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84148, USA. walter.wray@hsc.utah.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brachial Artery / physiology, ultrasonography Exercise / physiology* Female Hand / blood supply*, physiology*, ultrasonography Hand Strength / physiology* Hemodynamics / drug effects, physiology Humans Hyperemia / physiopathology Male Nitric Oxide / physiology* Nitric Oxide Synthase / antagonists & inhibitors Regional Blood Flow / drug effects, physiology Vasodilation / physiology* Vasodilator Agents / metabolism Young Adult omega-N-Methylarginine / physiology |
| Grant Support | |
ID/Acronym/Agency:
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AG-028403/AG/NIA NIH HHS; P01-HL-091830/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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