Document Detail

Progression to Adenocarcinoma in Barrett's Esophagus After Liver Transplantation.
MedLine Citation:
PMID:  21464795     Owner:  NLM     Status:  Publisher    
BACKGROUND.: The risk for development of certain malignancies after transplantation is well known. Especially in premalignant lesions of the skin and colon, rapid progression is described. The aim of this study is to evaluate the progress of Barrett's mucosa to adenocarcinoma of the esophagus after liver transplantation. METHODS.: Between 2000 and 2009, 895 patients underwent a liver transplantation in our department. All patients had an upper endoscopy as part of the evaluation before transplantation. Patients who had Barrett's mucosa described in their endoscopy report were identified. The records of these patients were retrospectively reviewed. RESULTS.: There were seven patients who had Barrett's mucosa in the preoperative endoscopy. Five of these patients (71%) developed an esophageal adenocarcinoma in a median time of 66 months after liver transplantation. One had stage II disease and four had stage III disease. Three of them underwent neoadjuvant therapy. All patients underwent an en bloc esophagectomy. One patient developed recurrent disease after 12 months and died 37 months after esophagectomy. The other four patients are still alive without recurrence and have a median survival of 16 months. CONCLUSION.: Esophageal cancer after liver transplantation is rare, whereas the risk for progression of Barrett's esophagus to adenocarcinoma is extremely high. Surveillance endoscopy with aggressive endoscopic treatment of the Barrett's is essential for these patients to prevent them from cancer death. Furthermore, immunosuppression therapy based on immunosuppressants with antitumoral effects should be preferred. The esophagectomy with neoadjuvant therapy is also in immunosuppressant patients feasible without increased risk for complications.
Arzu Oezcelik; Gernot M Kaiser; Alexander Dechêne; Juergen W Treckmann; Georgios C Sotiropoulos; Renate Reinhardt; Fuat H Saner; Andreas Paul
Related Documents :
17157445 - Prospective study on late renal toxicity following postoperative chemoradiotherapy in g...
17002675 - Renal oxygen delivery: matching delivery to metabolic demand.
21384505 - The interaction among donor characteristics, severity of liver disease, and the cost of...
21345005 - Long-term hepatic vascular access in the nonhuman primate for recurrent portal vein inf...
17364165 - Continuous renal replacement therapy is associated with less chronic renal failure than...
7919145 - Acute hypoxia and endogenous renal endothelin.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-1
Journal Detail:
Title:  Transplantation     Volume:  -     ISSN:  1534-6080     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Department of General, Visceral and Transplantation Surgery, University of Essen, Essen, Germany. 2 Department of Internal Medicine, Gastroenterology and Hepatology, University of Essen, Essen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bilateral Upper and Lower Eyelid Severe Psoriasiform Blepharitis: Case Report and Review of Literatu...
Next Document:  Mycophenolate mofetil initiation in renal transplant patients at different times posttransplantation...