Document Detail


Progression of precancerous lesions to oral cancer: results based on the Taiwan National Health Insurance Database.
MedLine Citation:
PMID:  23273345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Oral cancer (OC) is the leading cause of death from cancer in men between the ages of 25 and 44 in Taiwan. The survival rate for the last stage of OC is <20% while that for the earliest stage is >75%, which suggests the importance of the diagnosis of oral precancerous lesions (OPLs) in reducing OC mortality. The aim of this study was to analyze the time to OC event after OPL diagnosis, and to suggest the surveillance period necessary according to OPL type.
MATERIALS AND METHODS: This was a retrospective cohort study based on 1.0 million people randomly selected from the Taiwan National Health Insurance Database, which provided data on 3058 adult male patients aged ≥20 years who were diagnosed with OPL for the first time between 1996 and 2009. The patient population was divided into two groups according to the type of lesion: oral submucous fibrosis (OSF) or oral leukoplakia (OLE). Age-standardized incidence rate (ASIR) and hazards rate (HR) were then estimated.
RESULTS: The ASIR for OPL showed an increasing trend over the study period, the main contributor to this being OSF. The OSF group demonstrated a higher OC incidence rate than the OLE group.
CONCLUSION: Patients with both OLE and OSF carry a higher risk for OC than those with either OLE or OSF alone, and they may also experience malignant transformation at an earlier date (mostly within 5 years). The 5- and 10-year OC rate for both OLE and OSF was found to be 5% and around 10%, respectively. However, 10 years after the diagnosis of OPL, OSF carries a higher risk of developing into OC than OLE.
Authors:
Ie-Bin Lian; Yao-Ting Tseng; Che-Chun Su; Kuo-Yang Tsai
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Publication Detail:
Type:  Journal Article     Date:  2012-12-27
Journal Detail:
Title:  Oral oncology     Volume:  49     ISSN:  1879-0593     ISO Abbreviation:  Oral Oncol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-01     Completed Date:  2013-09-19     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  427-30     Citation Subset:  IM    
Copyright Information:
Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Cell Transformation, Neoplastic / pathology*
Cohort Studies
Databases, Factual
Disease Progression
Follow-Up Studies
Humans
Leukoplakia, Oral / pathology
Male
Middle Aged
Mouth Neoplasms / pathology*
Oral Submucous Fibrosis / pathology
Precancerous Conditions / pathology*
Retrospective Studies
Risk Factors
Taiwan
Time Factors
Young Adult
Comments/Corrections
Comment In:
J Evid Based Dent Pract. 2013 Dec;13(4):183-4   [PMID:  24237747 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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