Document Detail

Progression of ochratoxicosis in broiler chickens.
MedLine Citation:
PMID:  2905799     Owner:  NLM     Status:  MEDLINE    
The progression of effects induced by administration of ochratoxin A were characterized in young male broiler chickens (Hubbard x Hubbard). The experimental design consisted of four dietary treatments of ochratoxin A (0, 1.0, 2.0, and 4.0 micrograms ochratoxin A/g feed) and 11 replicates of 10 broilers/replicate. Broilers were housed in electrically heated batteries with feed and water available ad libitum. Broilers were weighed, bled, killed by cervical dislocation, and necropsied at 3, 6, 9, 12, 15, 18, and 21 days of age. Toxicity of ochratoxin A to broilers was evident as early as 6 days of age, when significant (P less than .05) growth depression occurred at 4.0 micrograms dietary ochratoxin A/g feed. Dietary ochratoxin A significantly increased the relative weights of the liver, kidney, spleen, pancreas, and gizzard. Anemia, characterized by a significant decrease in packed-cell volume and hemoglobin levels, was present during ochratoxicosis. Hepatotoxicity of dietary ochratoxin A was evident through an observed significant reduction in serum levels of total protein, albumin, globulin, cholesterol, triglyceride, and blood urea nitrogen, and a significant increase in the serum activities of gamma glutamyl transferase and cholinesterase. A significant increase in serum uric acid and creatinine levels was indicative of nephrotoxicity. These data provide a description of the progression of ochratoxicosis in broilers that should be useful in diagnosis and in improved understanding of ochratoxicosis.
W E Huff; L F Kubena; R B Harvey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Poultry science     Volume:  67     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1989-02-28     Completed Date:  1989-02-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1139-46     Citation Subset:  IM    
US Department of Agriculture, Veterinary Toxicology and Entomology Research Laboratory, College Station, Texas 77841.
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MeSH Terms
Blood Proteins
Blood Urea Nitrogen
Chickens / blood*
Cholesterol / blood
Cholinesterases / blood
Creatinine / blood
Hematocrit / veterinary
Hemoglobins / analysis
Ochratoxins / administration & dosage,  toxicity*
Organ Size / drug effects
Triglycerides / blood
Uric Acid / blood
gamma-Glutamyltransferase / blood
Reg. No./Substance:
0/Blood Proteins; 0/Hemoglobins; 0/Ochratoxins; 0/Triglycerides; 303-47-9/ochratoxin A; 57-88-5/Cholesterol; 60-27-5/Creatinine; 69-93-2/Uric Acid; EC; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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