Document Detail

Progression of mild cognitive impairment to Alzheimer's disease: improved diagnostic value of the combined use of N200 latency and beta-amyloid(1-42) levels.
MedLine Citation:
PMID:  19628938     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: The aim of this study was to investigate the role of cerebrospinal fluid beta-amyloid(1-42) levels and auditory event-related potentials (AERPs) in the progress of mild cognitive impairment (MCI) to Alzheimer's disease (AD). METHODS: In 53 MCI patients, lumbar puncture was performed and beta-amyloid(1-42) levels were determined. Twenty patients were reexamined after 11 months. During this period, 5 of them progressed to AD. Neuropsychological and ERP analyses were performed on all patients during both baseline and endpoint examinations. RESULTS: Compared to stable MCI patients, those that progressed to AD had significantly lower beta-amyloid(1-42) levels (Mann-Whitney test, Z = -2.952, p = 0.003; effect size r = -0.41) and significantly prolonged N200 latencies (Mann-Whitney test, Z = -3.561, p < 0.001, effect size r = -0.49). From ERP variables, only the N200 latency significantly correlated with beta-amyloid(1-42) levels (baseline examination: r(s) = -0.421, p = 0.002; follow-up examination: r(s) = -0.574, p = 0.008). CONCLUSIONS: The combined use of these two parameters enabled discrimination of stable MCI patients from those who developed AD, with 100% sensitivity and specificity. Therefore, this method could be of high diagnostic value for the early diagnosis of AD.
Vasileios T Papaliagkas; G Anogianakis; M N Tsolaki; G Koliakos; V K Kimiskidis
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Publication Detail:
Type:  Journal Article     Date:  2009-07-23
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  28     ISSN:  1421-9824     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-28     Completed Date:  2009-11-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  30-5     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Department of Experimental Physiology, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
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MeSH Terms
Alzheimer Disease / blood,  diagnosis*,  psychology*
Amyloid beta-Protein / cerebrospinal fluid*
Biological Markers
Cognition Disorders / blood,  diagnosis*,  psychology*
Discrimination (Psychology) / physiology
Disease Progression
Evoked Potentials, Auditory / physiology
Neuropsychological Tests
Peptide Fragments / cerebrospinal fluid*
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Biological Markers; 0/Peptide Fragments; 0/amyloid beta-protein (1-42)

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