| Progression of intermittent, small-angle, and variable esotropia in infancy. | |
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MedLine Citation:
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PMID: 17251463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Esotropia (ET) in infancy may initially manifest as a small-angle, variable-angle, or intermittent deviation. Some patients experience spontaneous resolution and become orthophoric. Others progress to constant large-angle ET and require surgery. The authors examined factors that may be associated with risk for progression to constant large-angle ET. METHODS: Seventy-seven infants who initially presented with intermittent, small (<20 prism diopter [pd]) or variable-angle ET at 2 to 12 months of age were followed up until the ET was resolved, the infants had surgery, or the parents or guardians refused surgery. All infants with refractive correction >/=+3.50 D were treated initially with glasses. Four risk factors were examined: prescription of occlusion therapy, initial visit before 6 months of age, presence of amblyopia, and abnormal stereoacuity. RESULTS: All 12 infants with small or variable angles progressed to constant large-angle ET and surgery. ET resolved spontaneously in 44.6% (29/65) infants in whom it was intermittent. Infants with intermittent ET who received patches as initial treatment and who had abnormal stereoacuity had 3.4x (95% confidence interval [CI], 1.83-6.29) and 3.4x (95% CI, 1.66-6.78) higher risk for progression to constant large-angle ET, respectively. Neither age at initial visit nor amblyopia presented risk for progression. CONCLUSIONS: Abnormal stereoacuity and occlusion therapy pose significant risks for progression from intermittent to constant large-angle ET. Intermittent ET that develops during the first year of life has a high likelihood of spontaneous resolution, whereas constant small-angle or variable-angle ET seldom resolves. |
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Authors:
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Valeria L N Fu; David R Stager; Eileen E Birch |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 48 ISSN: 0146-0404 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-25 Completed Date: 2007-03-01 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 661-4 Citation Subset: IM |
Affiliation:
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Pediatric Eye Research Laboratory, Retina Foundation of the Southwest, Dallas, Texas 75231, USA. vfu@retinafoundation.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Disease Progression Esotropia / physiopathology*, therapy Eyeglasses Follow-Up Studies Humans Infant Oculomotor Muscles / physiopathology* Ophthalmologic Surgical Procedures Remission, Spontaneous Risk Factors Sensory Deprivation Visual Acuity |
| Grant Support | |
ID/Acronym/Agency:
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EY05236/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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