Document Detail


Progression from Normal to Reduced Left Ventricular Ejection Fraction in Patients With Concentric Left Ventricular Hypertrophy After Long-Term Follow-Up.
MedLine Citation:
PMID:  21798496     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Whether concentric left ventricular (LV) hypertrophy (LVH) is a common precursor to depressed LV ejection fraction (EF) in humans is uncertain. From 1992 through 1994, 555 patients at our institution underwent echocardiography and had LVH (posterior or septal wall thickness ≥1.3 cm or concentric LVH noted) and normal LVEF. Of these, 220 (40%) had a follow-up assessment of LVEF by December 2008. The duration of follow-up was classified as short (≤7.5 years) or long (>7.5 years) term. The primary outcome was the development of a qualitatively depressed LVEF (mildly, moderately, or severely depressed). After a median follow-up of 7.5 years, 20% of the patients with concentric LVH developed a low LVEF. A low LVEF developed in 13% of subjects without interval myocardial infarction (MI) and 50% of subjects with interval MI during short-term follow-up (p <0.005). A low LVEF developed in 20% of subjects without interval MI and 44% of subjects with interval MI during long-term follow-up (p = 0.01). Of the subjects who developed a reduced LVEF, the relative wall thickness (median 0.5, 25th to 75th percentile 0.4 to 0.6) at follow-up was consistent with a concentric, rather than eccentric, phenotype. In conclusion, in patients with concentric LVH, the transition from a normal LVEF to a low LVEF was relatively infrequent (20%) after long-term follow-up in the absence of interval MI and usually did not result in a change in the LV geometry from a concentric to an eccentric phenotype.
Authors:
Arun Krishnamoorthy; Timothy Brown; Colby R Ayers; Sachin Gupta; J Eduardo Rame; Parag C Patel; David W Markham; Mark H Drazner
Related Documents :
8187116 - Predictors of myocardial infarction after distal embolization of coronary vessels with ...
19359536 - Cystatin c for enhancement of risk stratification in non-st elevation acute coronary sy...
11065236 - The effects of long-acting nitrates on 5-year cardiac events of patients with coronary ...
19423566 - Early angiography in patients with chronic kidney disease: a collaborative systematic r...
23369976 - Acute exposure to lead increases myocardial contractility independent of hypertension d...
1533256 - Response of the hypertrophied left ventricle to global ischemia. comparison of hyperkal...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-27
Journal Detail:
Title:  The American journal of cardiology     Volume:  -     ISSN:  1879-1913     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical Significance of a Single Coronary Artery Arising from the Right Sinus of Valsalva With the ...
Next Document:  Usefulness of Preoperative Stroke Volume as Strong Predictor of Left Ventricular Remodeling and Outc...