Document Detail


Progression of esophageal carcinoma by loss of EGF-STAT1 pathway.
MedLine Citation:
PMID:  11324766     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: In only a very limited number of cultured cell lines, epidermal growth factor (EGF), a potent mitogen for many kinds of cells, was shown to activate STAT1 (signal transducer and activator of transcription 1) protein, which can transmit signals that cause cell growth arrest and apoptosis. The purpose of this work is to elucidate the physiologic and/or pathological significance of this EGF-STAT1 pathway. MATERIALS AND METHODS: A series of cultured cell lines that had been established from surgical specimens of esophageal squamous cell carcinoma was studied for the existence of the EGF-STAT1 pathway. Normal esophageal squamous epithelial cells either explanted from non-neoplastic portions of surgically removed human esophageal tissue or in bovine esophageal epithelium in situ were examined as well. RESULTS: EGF treatment leads to a strong growth arrest in three of the 30 esophageal squamous cell carcinoma cell lines. STAT1 was found to be activated by EGF in the three cell lines but not in the others. EGF can also activate STAT1 in cultured normal esophageal squamous epithelial cells. STAT1 is at the activated state in the basal cell layer of the bovine esophageal epithelium. Notably, patients who had harbored the cancer cells with the EGF-STAT1 pathway had a dramatically better prognosis. DISCUSSION: The EGF-STAT1 pathway may be intrinsic to esophageal epithelial lineage of cells and is lost in a considerable fraction of the carcinomas. This loss appears to cause a significantly more malignant clinical course. These findings may point out a critical step in the progression of esophageal cancer and could lead to the development of useful clinical applications.
Authors:
G Watanabe; J Kaganoi; M Imamura; Y Shimada; A Itami; S Uchida; F Sato; M Kitagawa
Related Documents :
7295166 - Human squamous cell carcinoma. establishment and characterization of new permanent cell...
16416296 - Correlation of invasion and metastasis of cancer cells, and expression of the rad21 gen...
6210326 - Involucrin in squamous and basal cell carcinomas of the skin: an immunohistochemical st...
12760696 - Cytotoxicity of conventional and modified glass ionomer cements.
1306296 - Dna repair pathways in mammalian cells analyzed by isolation of acnu-sensitive chinese ...
6743286 - A proton n.m.r. study of iminodipeptide transport and hydrolysis in the human erythrocy...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer journal (Sudbury, Mass.)     Volume:  7     ISSN:  1528-9117     ISO Abbreviation:  Cancer J     Publication Date:    2001 Mar-Apr
Date Detail:
Created Date:  2001-04-27     Completed Date:  2001-08-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  100931981     Medline TA:  Cancer J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  132-9     Citation Subset:  IM    
Affiliation:
Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blotting, Northern
Carcinoma, Squamous Cell / metabolism*,  pathology
DNA-Binding Proteins / metabolism*
Disease Progression
Esophageal Neoplasms / metabolism*,  pathology
Esophagus / cytology
Female
Humans
Immunoblotting
Immunohistochemistry
Male
Receptor, Epidermal Growth Factor / metabolism*
STAT1 Transcription Factor
Signal Transduction*
Trans-Activators / metabolism*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/STAT1 Transcription Factor; 0/STAT1 protein, human; 0/Trans-Activators; EC 2.7.10.1/Receptor, Epidermal Growth Factor
Comments/Corrections
Comment In:
Cancer J. 2001 Mar-Apr;7(2):108-11   [PMID:  11324763 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Radiosurgery for brain metastases from primary lung carcinoma.
Next Document:  Induction chemotherapy followed by concomitant chemoradiotherapy in the treatment of locoregionally ...