| Progression of dopamine transporter decline in patients with the Parkinson variant of multiple system atrophy: a voxel-based analysis of [(123)I]β-CIT SPECT. | |
| | |
MedLine Citation:
|
PMID: 22460689 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: We characterized the progression of dopamine transporter (DAT) decline in the striatum and extrastriatal regions including the midbrain and pons of patients with the Parkinson variant of multiple system atrophy (MSA-P) and compared longitudinally collected SPECT results with those in a cohort of patients with Parkinson's disease (PD). METHODS: Eight patients with MSA-P (age 60.4 ± 7.7 years, disease duration 2.4 ± 1 years, UPDRS-III motor score 39.7 ± 4.7), and 11 patients with PD (age 61.2 ± 6.4 years, disease duration 2.4 ± 1.1 years, UPDRS-III motor score 18.9 ± 7.6) underwent a baseline and follow-up [(123)I]β-CIT SPECT investigation within a time period of 1.3 years. Statistical parametric mapping (SPM) and a repetitive ANOVA design were used to objectively localize the decline in DAT availability without having to make an a priori hypothesis as to its location. RESULTS: SPM localized significant reductions in [(123)I]β-CIT uptake in the dorsal brainstem of MSA-P patients compared to PD patients (p < 0.001) at baseline. Additional reductions in the DAT signal were localized in the caudate and anterior putamen of patients with MSA-P patients compared to PD patients at the follow-up examination (p < 0.001). Relative decline in tracer binding was evident in the caudate and anterior putamen of MSA-P patients compared to PD patients in the longitudinal analysis (p < 0.05), whereas no significant relative signal alteration was observed in the brainstem. CONCLUSION: In contrast to PD, the relatively higher rate of signal reduction in the caudate and anterior putamen is consistent with the faster disease progression reported in MSA-P. At baseline, the tracer uptake in the brainstem was already at very low levels in the MSA-P patients compared to that in healthy control subjects and did not progress any further, suggesting that the degeneration of monoaminergic neurons is almost complete early in the disease course. |
| | |
Authors:
|
Michael Nocker; Klaus Seppi; Eveline Donnemiller; Irene Virgolini; Gregor K Wenning; Werner Poewe; Christoph Scherfler |
Related Documents
:
|
22220279 - Peripheral arterial disease in patients presenting with acute coronary syndrome in six ... 21921549 - Language in als/ftld. 22190069 - Distressed personality is associated with lower psychological well-being and life satis... 21903459 - Nucleos(t)ide analogue treatment reduces apoptotic activity in patients with chronic he... 21983349 - The presence of -308a tnfa is associated with anemia and thrombocytopenia in patients w... 22180989 - Alkaline phosphatase: can it be considered as an indicator of liver fibrosis in non-alc... 8010339 - Clinical experience with atovaquone: a new drug for treating pneumocystis carinii pneum... 12119579 - Serum leptin concentration in obese patients with binge eating disorder. 12937309 - Nocturnal but not short hours quotidian hemodialysis requires an elevated dialysate cal... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-30 |
Journal Detail:
|
Title: European journal of nuclear medicine and molecular imaging Volume: - ISSN: 1619-7089 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria, Michael.Nocker@i-med.ac.at. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Effects of Syntactic Complexity on Processing Sentences in Noise.
Next Document: Ultra-fast microwave-assisted hydrothermal synthesis of long vertically aligned ZnO nanowires for dy...