Document Detail


Progression of cystic fibrosis lung disease as a function of serum immunoglobulin G levels: a 5-year longitudinal study.
MedLine Citation:
PMID:  6716217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seventy children with cystic fibrosis were studied over a 5-year period to assess the relationship between serum immunoglobulin G levels and progression of cystic fibrosis lung disease. Patients were grouped according to their serum IgG values (low, normal, or high) and evaluated with serial pulmonary function testing, radiographic and immunologic studies, and clinical observation. The children with persistent hypogammaglobulinemia G showed significantly better lung function, better weight for age, fewer hospitalizations for pulmonary exacerbations, less colonization with Pseudomonas aeruginosa, and slower decline in pulmonary functions than did age-matched patients with normal or high IgG levels. Death occurred in five of eight (63%) patients with hypergammaglobulinemia, three of 30 (10%) with normogammaglobulinemia, and one of 32 (3%) with hypogammaglobulinemia. No deaths occurred in the 15 patients with persistent hypogammaglobulinemia. These data indicate that children with cystic fibrosis and hypogammaglobulinemia G have milder lung disease and slower deterioration in pulmonary function than do age-matched patients with normal or elevated immunoglobulin G values. The mechanisms accounting for this finding are unclear.
Authors:
W B Wheeler; M Williams; W J Matthews; H R Colten
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  104     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-06-07     Completed Date:  1984-06-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  695-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Agammaglobulinemia / etiology
Child
Cystic Fibrosis / immunology*
Humans
Hypergammaglobulinemia / mortality
Immunoglobulin G / analysis*
Longitudinal Studies
Lung Diseases / diagnosis,  immunology*
Prognosis
Prospective Studies
Pseudomonas Infections / complications
Respiratory Function Tests
Grant Support
ID/Acronym/Agency:
HL07010-08/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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