Document Detail

Progression of bone marrow abnormalities in malignant hemopoietic dysplasia. Evaluation of cytological changes with serial bone marrow samples.
MedLine Citation:
PMID:  6947685     Owner:  NLM     Status:  MEDLINE    
Progression of bone marrow abnormalities in 12 patients with malignant (fatal) hemopoietic dysplasia (HD) was evaluated retrospectively in sequential bone marrow samples, using a simple morphological scoring technique. Special attention was paid to alterations in cytological abnormalities in the myeloid series. Patients who developed acute myeloid leukemia showed increasing scores during the clinical course and a rapid final increase in particularly myeloid nucleolar abnormalities. Patients who did not develop overt myeloid leukemia but died from bleeding and/or infection had low and stable scoring and showed no progression of cytological abnormalities. Repeated evaluation, especially of cytological changes in the bone marrow, and morphological scoring might be useful as predictive tools to estimate the risk of a leukemic transformation in some patients with HD.
J Lidbeck; J C Månson
Related Documents :
10989195 - Increased apoptosis of bone marrow cells and preserved proliferative capacity of select...
20683595 - Procollagen type i n-propeptide is a predictor of skeletal morbidity in patients with m...
2266805 - Localized in vivo proton spectroscopy of the bone marrow in patients with leukemia.
21352285 - Serum levels of interleukin-8, tumor necrosis factor-α and γ-interferon in egyptian p...
19690935 - Use of phase analysis of gated spect perfusion imaging to quantify dyssynchrony in pati...
22477595 - Prolongation of qrs duration and axis deviation in the right bundle branch block are no...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  210     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1981  
Date Detail:
Created Date:  1982-02-25     Completed Date:  1982-02-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bone Marrow / pathology*
Cell Transformation, Neoplastic
Leukemia, Erythroblastic, Acute / pathology
Leukemia, Myeloid, Acute / pathology
Middle Aged
Preleukemia / pathology*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Vasoactive intestinal polypeptide (VIP): effect on rabbit uterine smooth muscle in vivo and in vitro...
Next Document:  Pre-T chronic lymphocytic leukemia with common acute lymphoblastic leukemia antigen. A new immunolog...