Document Detail


Progression of bone marrow abnormalities in malignant hemopoietic dysplasia. Evaluation of cytological changes with serial bone marrow samples.
MedLine Citation:
PMID:  6947685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Progression of bone marrow abnormalities in 12 patients with malignant (fatal) hemopoietic dysplasia (HD) was evaluated retrospectively in sequential bone marrow samples, using a simple morphological scoring technique. Special attention was paid to alterations in cytological abnormalities in the myeloid series. Patients who developed acute myeloid leukemia showed increasing scores during the clinical course and a rapid final increase in particularly myeloid nucleolar abnormalities. Patients who did not develop overt myeloid leukemia but died from bleeding and/or infection had low and stable scoring and showed no progression of cytological abnormalities. Repeated evaluation, especially of cytological changes in the bone marrow, and morphological scoring might be useful as predictive tools to estimate the risk of a leukemic transformation in some patients with HD.
Authors:
J Lidbeck; J C Månson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  210     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1981  
Date Detail:
Created Date:  1982-02-25     Completed Date:  1982-02-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Bone Marrow / pathology*
Cell Transformation, Neoplastic
Female
Humans
Leukemia, Erythroblastic, Acute / pathology
Leukemia, Myeloid, Acute / pathology
Male
Middle Aged
Preleukemia / pathology*
Retrospective Studies
Risk

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