Document Detail

Progression of atherosclerosis in hemodialysis patients: effect of adiponectin on carotid intima media thickness.
MedLine Citation:
PMID:  18776705     Owner:  NLM     Status:  MEDLINE    
AIM: We investigated the parameters related to the progression of common carotid artery intima media thickness (IMT) in hemodialysis (HD) patients. METHODS: IMT was examined in 85 patients by ultrasonography at baseline and after 12 months. The difference in IMT between these two time points was calculated (DeltaIMT). We defined DeltaIMT< or =0.00 as 'progression', and DeltaIMT0.00 as 'stable'. Body fat distribution was calculated on computed tomography. Total adiponectin (T-Ad) and high molecular weight adiponectin (H-Ad) were measured by ELISA. RESULTS: There were no significant differences between the two groups in all profiles except for the ratio of H-Ad to T-Ad (HMWR) at baseline. In the 'progression' group, IMT increased from 1.56+/-0.89 to 1.77+/-0.94 mm (p<0.001) and visceral fat area (60.3+/-30.7 to 69.2+/-37.5, cm2; p<0.01) increased. In the 'stable' group, HMWR increased from 31.3+/-5.4 to 37.6+/-7.3% (p<0.001). Multiple logistic regression analysis selected DeltaHMWR (p=0.031, odds ratio=0.928) independently of IMT progression. The correlation coefficient was -0.254 (p=0.019) between DeltaIMT and DeltaHMWR. CONCLUSIONS: We found that an increase in HMWR was related to the stable state of IMT in HD patients.
Megumi Tsushima; Yuriko Terayama; Akishi Momose; Tomihisa Funyu; Chikara Ohyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  15     ISSN:  1880-3873     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-09-08     Completed Date:  2008-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  213-8     Citation Subset:  IM    
Oyokyo Kidney Research Institute, Hirosaki, Japan.
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MeSH Terms
Adiponectin / physiology*
Atherosclerosis / metabolism,  pathology*
Carotid Arteries / pathology*,  ultrasonography
Disease Progression
Logistic Models
Middle Aged
Renal Dialysis*
Tunica Intima / pathology*,  ultrasonography
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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