| Progression of atherosclerosis in hemodialysis patients: effect of adiponectin on carotid intima media thickness. | |
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MedLine Citation:
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PMID: 18776705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: We investigated the parameters related to the progression of common carotid artery intima media thickness (IMT) in hemodialysis (HD) patients. METHODS: IMT was examined in 85 patients by ultrasonography at baseline and after 12 months. The difference in IMT between these two time points was calculated (DeltaIMT). We defined DeltaIMT< or =0.00 as 'progression', and DeltaIMT0.00 as 'stable'. Body fat distribution was calculated on computed tomography. Total adiponectin (T-Ad) and high molecular weight adiponectin (H-Ad) were measured by ELISA. RESULTS: There were no significant differences between the two groups in all profiles except for the ratio of H-Ad to T-Ad (HMWR) at baseline. In the 'progression' group, IMT increased from 1.56+/-0.89 to 1.77+/-0.94 mm (p<0.001) and visceral fat area (60.3+/-30.7 to 69.2+/-37.5, cm2; p<0.01) increased. In the 'stable' group, HMWR increased from 31.3+/-5.4 to 37.6+/-7.3% (p<0.001). Multiple logistic regression analysis selected DeltaHMWR (p=0.031, odds ratio=0.928) independently of IMT progression. The correlation coefficient was -0.254 (p=0.019) between DeltaIMT and DeltaHMWR. CONCLUSIONS: We found that an increase in HMWR was related to the stable state of IMT in HD patients. |
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Authors:
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Megumi Tsushima; Yuriko Terayama; Akishi Momose; Tomihisa Funyu; Chikara Ohyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of atherosclerosis and thrombosis Volume: 15 ISSN: 1880-3873 ISO Abbreviation: J. Atheroscler. Thromb. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-09-08 Completed Date: 2008-12-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: Japan |
Other Details:
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Languages: eng Pagination: 213-8 Citation Subset: IM |
Affiliation:
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Oyokyo Kidney Research Institute, Hirosaki, Japan. staff@oyokyo.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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physiology* Aged Atherosclerosis / metabolism, pathology* Carotid Arteries / pathology*, ultrasonography Disease Progression Female Humans Logistic Models Male Middle Aged Renal Dialysis* Tunica Intima / pathology*, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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