Document Detail

Progression of atherosclerosis after venous coronary artery bypass graft surgery: a 15-year follow-up study.
MedLine Citation:
PMID:  9184285     Owner:  NLM     Status:  MEDLINE    
We investigated the influence of progression of atherosclerosis on clinical outcome in a cohort of 428 consecutive patients with isolated venous coronary artery bypass graft surgery followed prospectively for 15 years. In 189 patients 307 repeat coronary angiograms were performed because of recurrent signs of ischemia. Progression in the native coronary circulation only was found in 38 angiograms (12%), in both the native circulation and in venous grafts in 66 angiograms (21%), in venous grafts only in 135 angiograms (44%), and no progression was found in 68 angiograms (22%). In all the angiographies with a proven progression in the native coronary arteries, 40% was found to be distal to a vein graft insertion. In multivariate analysis the number of distal anastomoses predicts progression in both the native circulation and in venous grafts. Thus, progression is determined by the extensiveness of coronary artery disease at operation. Also, the interval between operation and repeat angiography predicts progression in the native circulation. We conclude that clinical outcome is also determined by progression in the native coronary circulation. Secondary prevention may, therefore, benefit not only the long-term result in patients with venous bypass grafts but probably also in patients with any type of coronary bypass surgery.
B L van Brussel; H W Plokker; A A Voors; S M Ernst; H C Kelder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular diagnosis     Volume:  41     ISSN:  0098-6569     ISO Abbreviation:  Cathet Cardiovasc Diagn     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-07-29     Completed Date:  1997-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7508512     Medline TA:  Cathet Cardiovasc Diagn     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  141-50     Citation Subset:  IM    
Department of Cardiology, Diaconessenhuis, Eindhoven, The Netherlands.
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MeSH Terms
Arteriosclerosis / etiology*,  physiopathology
Coronary Artery Bypass / adverse effects*
Follow-Up Studies
Middle Aged
Multivariate Analysis
Risk Factors
Comment In:
Cathet Cardiovasc Diagn. 1997 Jun;41(2):151   [PMID:  9184286 ]

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