| Progression of Kaposi sarcoma associated with iatrogenic Cushing syndrome in a person with HIV/AIDS. | |
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MedLine Citation:
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PMID: 18333287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This case report describes an exacerbation of AIDS-associated Kaposi sarcoma (KS) in the setting of iatrogenic Cushing syndrome caused by an interaction between ritonavir-boosted atazanavir and fluticasone. Discontinuation of fluticasone resulted in resolution of the cutaneous KS. Clinicians should be aware of this potential drug-drug interaction that can result in increased corticosteroid levels. Inhaled corticosteroids should be used cautiously in persons with HIV/AIDS who have a history of KS and are being treated with a boosted atazanavir regimen because this can potentially exacerbate KS. |
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Authors:
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Sadao Jinno; Cyril Goshima |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The AIDS reader Volume: 18 ISSN: 1053-0894 ISO Abbreviation: AIDS Read Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-22 Completed Date: 2008-03-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9206753 Medline TA: AIDS Read Country: United States |
Other Details:
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Languages: eng Pagination: 100-4 Citation Subset: IM; X |
Affiliation:
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Department of Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Androstadienes
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adverse effects* Anti-Inflammatory Agents / adverse effects* Cushing Syndrome* / complications, drug therapy Drug Interactions HIV Infections* / complications, drug therapy HIV Protease Inhibitors / adverse effects* Humans Iatrogenic Disease Male Middle Aged Oligopeptides / adverse effects Pyridines / adverse effects Ritonavir / adverse effects Sarcoma, Kaposi / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Androstadienes; 0/Anti-Inflammatory Agents; 0/HIV Protease Inhibitors; 0/Oligopeptides; 0/Pyridines; 0/Ritonavir; 198904-31-3/atazanavir; 90566-53-3/fluticasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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