| Progression of coronary artery disease during long-term follow-up of the Swiss Interventional Study on Silent Ischemia Type II (SWISSI II). | |
| | |
MedLine Citation:
|
PMID: 20513067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: This study evaluates cardiovascular risk factors associated with progression of coronary artery disease (CAD) in patients with silent ischemia following myocardial infarction. HYPOTHESIS: Coronary artery disease only progresses slowly with comprehensive risk factor intervention. METHODS: A total of 104 of 201 patients (51.7%) of the Swiss Interventional Study on Silent Ischemia Type II (SWISSI II) with baseline and follow-up coronary angiography were included. All patients received comprehensive cardiovascular risk factor intervention according to study protocol. Logistic regression was used to evaluate associations between baseline cardiovascular risk factors and CAD progression. RESULTS: The mean duration of follow-up was 10.3+/-2.4 years. At baseline, 77.9% of patients were smokers, 45.2% had hypertension, 73.1% had dyslipidemia, 7.7% had diabetes, and 48.1% had a family history of CAD. At last follow-up, only 27 patients of the initial 81 smokers still smoked, only 2.1% of the patients had uncontrolled hypertension, 10.6% of the patients had uncontrolled dyslipidemia, and 2.1% of the patients had uncontrolled diabetes. Coronary artery disease progression was found in up to 81 (77.9%) patients. Baseline diabetes and younger age were associated with increased odds of CAD progression. The time interval between baseline and follow-up angiography was also associated with CAD progression. CONCLUSION: Coronary artery disease progression was highly prevalent in these patients despite comprehensive risk factor intervention. Further research is needed to optimize treatment of known risk factors and to identify other unknown and potentially modifiable risk factors. |
| | |
Authors:
|
Andreas W Schoenenberger; Peiman Jamshidi; Richard Kobza; Michel Zuber; Andreas E Stuck; Matthias Pfisterer; Paul Erne |
Related Documents
:
|
17433487 - The additional prognostic power of diabetes mellitus on coronary flow reserve in patien... 15071797 - Lipoprotein (a) in coronary artery disease in indian population. 18690157 - Diagnostic and prognostic value of cardiac magnetic resonance imaging in assessing myoc... 8160217 - Cardiac prognosis of patients with carotid stenosis and no history of coronary artery d... 153707 - Relationship of atrial fibrillatory wave amplitude to left atrial size and etiology of ... 11122437 - Sequential changes in localization of repair-related proteins (heat shock protein 70, u... |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical cardiology Volume: 33 ISSN: 1932-8737 ISO Abbreviation: Clin Cardiol Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-05-31 Completed Date: 2010-09-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 289-95 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Wiley Periodicals, Inc. |
Affiliation:
|
Department of Geriatrics, Inselspital, Bern University Hospital, and Spital Netz Bern Ziegler, and University of Bern, Switzerland. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT00387231 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Angioplasty, Transluminal, Percutaneous Coronary* Antihypertensive Agents / therapeutic use Antilipemic Agents / therapeutic use Cardiovascular Agents / therapeutic use* Chi-Square Distribution Coronary Angiography Coronary Stenosis / etiology*, radiography, therapy Disease Progression Female Humans Hypoglycemic Agents / therapeutic use Logistic Models Male Middle Aged Myocardial Infarction / etiology*, radiography, therapy Myocardial Ischemia / etiology*, radiography, therapy Odds Ratio Risk Assessment Risk Factors Severity of Illness Index Smoking Cessation Switzerland Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 0/Antilipemic Agents; 0/Cardiovascular Agents; 0/Hypoglycemic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The association of statin use and statin type and cognitive performance: analysis of the reasons for...
Next Document: Effects of stem cell therapy on left ventricular remodeling after acute myocardial infarction: a met...