| Progression of Alcoholic or Non-Alcoholic Steatohepatitis; Common Metabolic Aspects of Innate Immune System and Oxidative Stress. | |
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MedLine Citation:
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PMID: 21150132 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Growing evidence indicates that the innate immune system and oxidative stress caused by gut-derived endotoxins play a key role in alcoholic liver disease (ALD). Intracellular mechanisms associated with endotoxin-induced signaling play a crucial role in the initiation and progression of ALD. It is now widely accepted that activation of the innate immune system and increased release of pro-inflammatory cytokines and other mediators play an important role in the development of ALD. Accumulating evidence suggests that alcohol-mediated upregulation of CYP2E1 expression may initiate lipid peroxidation via reactive oxygen species (ROS). Non-alcoholic steatohepatitis (NASH) is a liver disease characterized by histopathological features similar to those observed in ALD, in the absence of significant alcohol consumption. Initial efforts to clarify the mechanisms that promote the progression from steatosis to steatohepatitis somewhat artificially divided disease mechanisms into "first and second" hit. This model considered the development of steatosis to be the "first hit", increasing the sensitivity of the liver to the putative "second hit", leading to hepatocyte injury, inflammation and oxidative stress. We have emphasized the important role of gut-derived bacterial toxins, the innate immune system, and oxidative stress in the common pathogenic mechanism in ALD or NASH progressions. |
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Authors:
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Shuhei Sakaguchi; Shougo Takahashi; Takamitsu Sasaki; Takeshi Kumagai; Kiyoshi Nagata |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-7 |
Journal Detail:
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Title: Drug metabolism and pharmacokinetics Volume: - ISSN: 1880-0920 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101164773 Medline TA: Drug Metab Pharmacokinet Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Environmental and Health Science, Tohoku Pharmaceutical University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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