Document Detail


Progress on the transcriptomics of carcinogenic liver flukes of humans--unique biological and biotechnological prospects.
MedLine Citation:
PMID:  20673796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Liver flukes, such as Clonorchis sinensis and Opisthorchis viverrini, are food-borne parasites that have a major impact on the health of humans and animals, particularly in Asia. However, the impact of C. sinensis and O. viverrini, in particular, is exacerbated in that these parasites can induce a malignant, untreatable cancer (cholangiocarcinoma, CCA) in chronically infected people. As a result, these flukes are classified as Group 1 carcinogens. Despite their substantial socio-economic importance, little is known about these parasites and their relationship with the definitive hosts at the molecular level. Here, we provide a background on these two carcinogenic flukes and review recent progress on characterizing their transcriptomes using next-generation technologies. We also describe the prospects that the transcriptomes of C. sinensis and O. viverrini provide as a resource for future -omic explorations and efforts to develop improved methods of intervention and control against these important pathogens and CCA, leading to biotechnological outcomes.
Authors:
Neil D Young; Aaron R Jex; Cinzia Cantacessi; Bronwyn E Campbell; Thewarach Laha; Woon-Mok Sohn; Banchob Sripa; Alex Loukas; Paul J Brindley; Robin B Gasser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-07-29
Journal Detail:
Title:  Biotechnology advances     Volume:  28     ISSN:  1873-1899     ISO Abbreviation:  Biotechnol. Adv.     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8403708     Medline TA:  Biotechnol Adv     Country:  England    
Other Details:
Languages:  eng     Pagination:  859-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Veterinary Science, The University of Melbourne, Werribee, Victoria, Australia. nyoung@unimelb.edu.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Biotechnology*
Cholangiocarcinoma / parasitology,  therapy
Fasciola hepatica / genetics*
Gene Expression Profiling*
Humans
Liver Neoplasms / parasitology*,  pathology
Sequence Analysis, DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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