Document Detail


Progress and problems in understanding and managing primary Epstein-Barr virus infections.
MedLine Citation:
PMID:  21233512     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epstein-Barr virus (EBV) is a gammaherpesvirus that infects a large fraction of the human population. Primary infection is often asymptomatic but results in lifelong infection, which is kept in check by the host immune system. In some cases, primary infection can result in infectious mononucleosis. Furthermore, when host-virus balance is not achieved, the virus can drive potentially lethal lymphoproliferation and lymphomagenesis. In this review, we describe the biology of EBV and the host immune response. We review the diagnosis of EBV infection and discuss the characteristics and pathogenesis of infectious mononucleosis. These topics are approached in the context of developing therapeutic and preventative strategies.
Authors:
Oludare A Odumade; Kristin A Hogquist; Henry H Balfour
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical microbiology reviews     Volume:  24     ISSN:  1098-6618     ISO Abbreviation:  Clin. Microbiol. Rev.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-14     Completed Date:  2011-04-14     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  8807282     Medline TA:  Clin Microbiol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-209     Citation Subset:  IM    
Affiliation:
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, MMC 437, 420 Delaware St. SE, Minneapolis, MN 55455-0392, USA.
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MeSH Terms
Descriptor/Qualifier:
Epstein-Barr Virus Infections / diagnosis*,  therapy*
Herpesvirus 4, Human / isolation & purification,  pathogenicity*
Humans
Grant Support
ID/Acronym/Agency:
DK 13083/DK/NIDDK NIH HHS; F31AI084524/AI/NIAID NIH HHS; T32-CA009138/CA/NCI NIH HHS
Comments/Corrections

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