Document Detail


Progress and opportunities for tissue-engineered skin.
MedLine Citation:
PMID:  17314974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tissue-engineered skin is now a reality. For patients with extensive full-thickness burns, laboratory expansion of skin cells to achieve barrier function can make the difference between life and death, and it was this acute need that drove the initiation of tissue engineering in the 1980s. A much larger group of patients have ulcers resistant to conventional healing, and treatments using cultured skin cells have been devised to restart the wound-healing process. In the laboratory, the use of tissue-engineered skin provides insight into the behaviour of skin cells in healthy skin and in diseases such as vitiligo, melanoma, psoriasis and blistering disorders.
Authors:
Sheila MacNeil
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature     Volume:  445     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-22     Completed Date:  2007-03-19     Revised Date:  2007-08-13    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  874-80     Citation Subset:  IM    
Affiliation:
The Tissue Engineering Group, Department of Engineering Materials and Division of Biomedical Sciences and Medicine, Kroto Research Institute, North Campus, University of Sheffield, Broad Lane, Sheffield S3 7HQ, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Melanoma / pathology,  surgery,  therapy
Skin / cytology,  pathology,  surgery*
Skin Diseases / pathology,  surgery,  therapy*
Skin Pigmentation / physiology
Tissue Engineering / adverse effects,  methods*,  trends*
Wound Healing / physiology
Grant Support
ID/Acronym/Agency:
//Wellcome Trust

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