Document Detail

Progress in research into the mechanism of Radix salviae miltiorrhizae in treatment of acute pancreatitis.
MedLine Citation:
PMID:  17085332     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute pancreatitis (AP) is a common acute abdomen with high mortality, multiple complications and complicated causes. There is no effective therapy for AP. Radix salviae miltiorrhizae (Danshen), a traditional herbal medicine, has a low price and a wide range of clinical applications. It is effective to promote blood flow, eliminate stagnancy, and relieve pain. It is also found to be effective in treating AP. We reviewed the progress in research into the mechanism of Radix salviae miltiorrhizae in treatment of AP. DATA SOURCES: An English-language literature search was conducted using MEDLINE (1988-2005) on Radix salviae miltiorrhizae (Danshen) and acute pancreatitis. RESULTS: The mechanisms of Danshen in the treatment of AP include improvement of microcirculatory disturbances; elimination of oxygen free radicals; modulation of the metabolism of lipid inflammatory mediator; and blocking of calcium inflow and prevention of calcium overload. CONCLUSION: Danshen can effectively reduce the mortality and complications of AP.
Xi-Ping Zhang; Zhi-Jun Li; Da-Ren Liu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Hepatobiliary & pancreatic diseases international : HBPD INT     Volume:  5     ISSN:  1499-3872     ISO Abbreviation:  HBPD INT     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-06     Completed Date:  2007-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101151457     Medline TA:  Hepatobiliary Pancreat Dis Int     Country:  China    
Other Details:
Languages:  eng     Pagination:  501-4     Citation Subset:  IM    
Department of General Surgery, Hangzhou First People's Hospital, Hangzhou 310006, China.
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MeSH Terms
Acute Disease
Calcium / metabolism
Inflammation Mediators / metabolism
Microcirculation / drug effects
Pancreas / blood supply,  drug effects*,  metabolism
Pancreatitis / drug therapy*,  metabolism
Plant Extracts / pharmacology*,  therapeutic use
Reactive Oxygen Species / metabolism
Salvia miltiorrhiza*
Reg. No./Substance:
0/Inflammation Mediators; 0/Plant Extracts; 0/Reactive Oxygen Species; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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