| Progress in research into the mechanism of Radix salviae miltiorrhizae in treatment of acute pancreatitis. | |
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MedLine Citation:
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PMID: 17085332 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Acute pancreatitis (AP) is a common acute abdomen with high mortality, multiple complications and complicated causes. There is no effective therapy for AP. Radix salviae miltiorrhizae (Danshen), a traditional herbal medicine, has a low price and a wide range of clinical applications. It is effective to promote blood flow, eliminate stagnancy, and relieve pain. It is also found to be effective in treating AP. We reviewed the progress in research into the mechanism of Radix salviae miltiorrhizae in treatment of AP. DATA SOURCES: An English-language literature search was conducted using MEDLINE (1988-2005) on Radix salviae miltiorrhizae (Danshen) and acute pancreatitis. RESULTS: The mechanisms of Danshen in the treatment of AP include improvement of microcirculatory disturbances; elimination of oxygen free radicals; modulation of the metabolism of lipid inflammatory mediator; and blocking of calcium inflow and prevention of calcium overload. CONCLUSION: Danshen can effectively reduce the mortality and complications of AP. |
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Authors:
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Xi-Ping Zhang; Zhi-Jun Li; Da-Ren Liu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Hepatobiliary & pancreatic diseases international : HBPD INT Volume: 5 ISSN: 1499-3872 ISO Abbreviation: HBPD INT Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-06 Completed Date: 2007-02-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101151457 Medline TA: Hepatobiliary Pancreat Dis Int Country: China |
Other Details:
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Languages: eng Pagination: 501-4 Citation Subset: IM |
Affiliation:
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Department of General Surgery, Hangzhou First People's Hospital, Hangzhou 310006, China. zxp99688@vip.163.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Calcium / metabolism Humans Inflammation Mediators / metabolism Microcirculation / drug effects Pancreas / blood supply, drug effects*, metabolism Pancreatitis / drug therapy*, metabolism Phytotherapy* Plant Extracts / pharmacology*, therapeutic use Reactive Oxygen Species / metabolism Salvia miltiorrhiza* |
| Chemical | |
Reg. No./Substance:
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0/Inflammation Mediators; 0/Plant Extracts; 0/Reactive Oxygen Species; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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